Abstract

Psyllium has been explored for various food and pharmaceutical applications. Recently, its therapeutic action against cancer has been reported. Hence, herein in this research it has been modified to develop hydrogels through graft copolymerization reaction for use as sustained drug delivery carriers for anti-cancer drug “5-fluorouracil” (FU) to enhance the therapeutic potential. Synthesis of hydrogels was carried out by grafting of poly(2-hydroxypropyl methacrylate) and poly(acrylamide) onto psyllium in the presence of crosslinker. Polymers were characterized by cryo-SEM, AFM, XRD, ¹³C-NMR, and TGA techniques, beside evaluation of swelling, drug release, blood compatibility, mucoadhesion, antioxidant properties and gel strength of the hydrogels. The porous network structure with rough surface was observed in cryo-SEM and AFM images of the samples. Release of FU from psy-cl-poly(HPMA-co-AAm) polymer occurred with non-Fickian diffusion in sustained manner. These hydrogels were mucoadhesive (work of adhesion = 8.45 ± 0.32 N mm), non-haemolytic (haemolytic index = 1.05 ± 0.07%), and antioxidant (with 19.12 ± 0.14% inhibition in DPPH assay) in nature, therefore they could be used as slow drug delivery carriers for ailments associated GIT system.

中文翻译：

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车前子多糖–甲基丙烯酸2-羟丙酯-聚丙烯酰胺水凝胶的合成与表征

摘要

洋车前子已被探索用于各种食品和制药应用。最近，已经报道了其对癌症的治疗作用。因此，本文中该研究已被修改以通过接枝共聚反应开发水凝胶，以用作抗癌药物“ 5-氟尿嘧啶”（FU）的持续药物递送载体，以增强治疗潜力。水凝胶的合成是通过在交联剂存在下将聚甲基丙烯酸2-羟丙酯和聚丙烯酰胺接枝到车前草上进行的。聚合物通过cryo-SEM，AFM，XRD，¹³表征用C-NMR和TGA技术评估水凝胶的溶胀，药物释放，血液相容性，粘膜粘附性，抗氧化性和凝胶强度。在样品的冷冻SEM和AFM图像中观察到具有粗糙表面的多孔网络结构。FU从psy - cl - poly （HPMA-co-AAm）聚合物中释放出来并持续发生非Fickian扩散。这些水凝胶本质上具有粘膜粘附性（粘附力= 8.45±0.32 N mm），非溶血性（溶血指数= 1.05±0.07％）和抗氧化剂（在DPPH分析中具有19.12±0.14％的抑制作用），因此可以使用作为与疾病相关的GIT系统的慢速药物输送载体。