Skip to main content
SpringerLink
Log in

Synthesis and Characterization of Psyllium Polysaccharide–Poly(2-hydroxypropyl methacrylate)−Poly(acrylamide) Hydrogels for Use in Sustained Drug Delivery Applications

  • MEDICAL POLYMERS
  • Published:
Polymer Science, Series B Aims and scope Submit manuscript

Abstract

Psyllium has been explored for various food and pharmaceutical applications. Recently, its therapeutic action against cancer has been reported. Hence, herein in this research it has been modified to develop hydrogels through graft copolymerization reaction for use as sustained drug delivery carriers for anti-cancer drug “5-fluorouracil” (FU) to enhance the therapeutic potential. Synthesis of hydrogels was carried out by grafting of poly(2-hydroxypropyl methacrylate) and poly(acrylamide) onto psyllium in the presence of crosslinker. Polymers were characterized by cryo-SEM, AFM, XRD, 13C-NMR, and TGA techniques, beside evaluation of swelling, drug release, blood compatibility, mucoadhesion, antioxidant properties and gel strength of the hydrogels. The porous network structure with rough surface was observed in cryo-SEM and AFM images of the samples. Release of FU from psy-cl-poly(HPMA-co-AAm) polymer occurred with non-Fickian diffusion in sustained manner. These hydrogels were mucoadhesive (work of adhesion = 8.45 ± 0.32 N mm), non-haemolytic (haemolytic index = 1.05 ± 0.07%), and antioxidant (with 19.12 ± 0.14% inhibition in DPPH assay) in nature, therefore they could be used as slow drug delivery carriers for ailments associated GIT system.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1.
Fig. 2.
Fig. 3.
Fig. 4.
Fig. 5.
Fig. 6.
Fig. 7.

Similar content being viewed by others

REFERENCES

  1. L. Tong, C. Ahn, E. Symanski, D. Lai, and X. L. Du, Ann. Oncol. 25, 1234 (2014).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. R. F. Donnelly, P. A. McCarron, M. M. Tunney, and A. D. Woolfson, J. Photochem. Photobiol., B 86, 59 (2007).

    Article  CAS  Google Scholar 

  3. S. Singh, S. Jain, M. S. Muthu, S. Tiwari, and R. Tilak, AAPS PharmSciTech 9, 660 (2008).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. S. R. Abulateefeh, S. G. Spain, K. J. Thurecht, J. W. Aylott, W. Chan, M. C. Garnett, and C. Alexander, Biomater. Sci. 1, 434 (2013).

    Article  CAS  PubMed  Google Scholar 

  5. T. Nagai and Y. Machida, Adv. Drug Delivery Rev. 11, 179 (1993).

    Article  CAS  Google Scholar 

  6. Y. Sudhakar, K. Kuotsu, and A. K. Bandyopadhyay, J. Controlled Release 114, 15 (2006).

    Article  CAS  Google Scholar 

  7. N. S. Madhav, A. K. Shakya, P. Shakya, and K. Singh, J. Controlled Release 140, 2 (2009).

    Article  CAS  Google Scholar 

  8. H. Tu, Y. Qu, X. Hu, Y. Yin, H. Zheng, P. Xu, and F. Xiong, Carbohydr. Polym. 82, 440 (2010).

    Article  CAS  Google Scholar 

  9. K. M. Rao, S. Nagappan, D. J. Seo, and C. S. Ha, Appl. Clay Sci. 97, 33 (2014).

    Article  CAS  Google Scholar 

  10. M. Shahid, S.A. Bukhari, Y. Gul, H. Munir, F. Anjum, M. Zuber, T. Jamil, and K. M. Zia, Int. J. Biol. Macromol. 62, 172 (2013).

    Article  CAS  PubMed  Google Scholar 

  11. Y. S. R. Krishnaiah, V. Satyanarayana, B. D. Kumar, and R. S. Karthikeyan, Eur. J. Pharm. Sci. 16, 185 (2002).

    Article  CAS  PubMed  Google Scholar 

  12. I. Kavianinia, P. G. Plieger, N. J. Cave, G. Gopakumar, M. Dunowska, N. G. Kandile, and D. R. K. Harding, Int. J. Biol. Macromol. 85, 539 (2016).

    Article  CAS  PubMed  Google Scholar 

  13. M. Prabaharan, Int. J. Biol. Macromol. 49, 117 (2011).

    Article  CAS  PubMed  Google Scholar 

  14. Y. Yin, Y. Yang, and H. Xu, J. Appl. Polym. Sci. 83, 2835 (2002).

    Article  CAS  Google Scholar 

  15. B. B. Mandal, S. Kapoor, and S. C. Kundu, Biomaterials 30, 2826 (2009).

    Article  CAS  PubMed  Google Scholar 

  16. B. Mukherjee, A. Samanta and S. C. Dinda, Trends Appl. Sci. Res. 1, 309 (2006).

    Article  CAS  Google Scholar 

  17. V. U. R. M. Sowdhamini, B. Sirisha, and A. Pratyusha, Int. J. Pharm. Invest. 2, 35 (2015).

    Google Scholar 

  18. F. Fernandez-Banares, J. Hinojosa, J. L. Sanchez-Lombrana, E. Navarro, J. F. Martinez-Salmeron, A. Garcia-Puges, F. Gonzalez-Huix, J. Riera, V. Gonzalez-Lara, F. Dominguez-Abascal, J. J. Gine, J. Moles, F. Gomollon, and M. A. Gassull, Am. J. Gastroenterol. 94, 427 (1999).

    CAS  PubMed  Google Scholar 

  19. M. R. Clausen, H. Bonnen, and P. B. Mortensen, Gut 32, 923 (1991).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  20. J. A. Market and M. H. Fischer, Proc. Nutr. Soc. 62, 207 (2003).

    Article  CAS  Google Scholar 

  21. J. F. Kennedy, J. S. Sandhu, and D. A. T. Southgate, Carbohydr. Res. 75, 265 (1979).

    Article  CAS  Google Scholar 

  22. B. Singh, Int. J. Pharm. 334, 1 (2007).

    Article  CAS  PubMed  Google Scholar 

  23. N. Zhang, Y. Yin, S. J. Xu, and W. S. Chen, Molecules 13, 1551 (2008).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  24. N. A. Peppas and N. K. Mongia, Eur. J. Pharm. Biopharm. 43, 51 (1997).

    Article  CAS  Google Scholar 

  25. G. Chang, Y. Chen, Y. Li, S. Li, F. Huang, Y. Shen, and A. Xie, Carbohydr. Polym. 122, 336 (2015).

    Article  CAS  PubMed  Google Scholar 

  26. S. Tanpichai and K. Oksman, Composites, Part A 88, 226 (2016).

    Article  CAS  Google Scholar 

  27. P. L. Ritger and N. A. Peppas, J. Controlled Release 5, 23 (1987).

    Article  CAS  Google Scholar 

  28. P. L. Ritger and N. A. Peppas, J. Controlled Release 5, 37 (1987).

    Article  CAS  Google Scholar 

  29. M. H. Shoaib, J. Tazen, H. A. Merchant, and R. I. Yousuf, Pak. J. Pharm. Sci. 19, 119 (2006).

    CAS  PubMed  Google Scholar 

  30. A. G. Sullad, L. S. Manjeshwar, and T. M. Aminabhavi, Ind. Eng. Chem. Res. 49, 7323 (2010).

    Article  CAS  Google Scholar 

  31. K. S. C. R. D. Santos, J. F. J. Coelho, P. Ferreira, I. Pinto, S. G. Lorenzetti, E. I. Ferreira, O. Z. Higa, and M. H. Gil, Int. J. Pharm. 310, 37 (2006).

    Article  PubMed  CAS  Google Scholar 

  32. American Society for Testing Materials, ASTM F 756-00 (Philadelphia, 2000).

  33. G. Gorczyca, R. Tylingo, P. Szweda, E. Augustin, M. Sadowska, and S. Milewski, Carbohydr. Polym. 102, 901 (2014).

    Article  CAS  PubMed  Google Scholar 

  34. M. Curcio, F. Puoci, F. Lemma, O. I. Parisi, G. Cirillo, U. G. Spizzirri, and N. Picci, J. Agric. Food Chem. 57, 5933 (2009).

    Article  CAS  PubMed  Google Scholar 

  35. N. Thirawong, J. Nunthanid, S. Puttipipatkhachorn, and P. Srimornsak, Eur. J. Pharm. Biopharm. 67, 132 (2007).

    Article  CAS  PubMed  Google Scholar 

  36. N. Buchtova, A. D’orlando, P. Judeinstein, O. Chauvet, P. Weiss, and J. Le Bideau, Carbohydr. Polym. 202, 404 (2018).

    Article  CAS  PubMed  Google Scholar 

  37. M. Chang, X. Liu, L. Meng, X. Wang, and J. Ren, Pharmaceutics 10, 261 (2018).

    Article  CAS  PubMed Central  Google Scholar 

  38. M. Munz, Appl. Surf. Sci. 279, 300 (2013).

    Article  CAS  Google Scholar 

  39. D. Das, R. Das, P. Ghosh, S. Dhara, A. B. Panda, and S. Pal, RSC Adv. 3, 25340 (2013).

  40. E. Andrzejewska-Golec, S. Ofterdinger-Daegel, I. Calis, and L. Swiatek, Plant Syst. Evol. 185, 85 (1993).

    Article  CAS  Google Scholar 

  41. H. Ramadan, T. Coradin, S. Masse, and H. El-Rassy, Silicon 3, 63 (2011).

    Article  CAS  Google Scholar 

  42. X. M. Liu, L. D. Quan, J. Tian, Y. Alnouti, K. Fu, G. M. Thiele, and D. Wang, Pharm. Res. 25, 2910 (2008).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  43. I. V. Averianov, V. A. Korzhikov-Vlakh, Y. E. Moskalenko, V. E. Smirnova, and T. B. Tennikova, Mendeleev Commun. 27, 574 (2017).

    Article  CAS  Google Scholar 

  44. E. E. Khozemy, S. M. Nasef, and G. A. Mahmoud, Adv. Polym. Technol. 37, 3252 (2018).

    Article  CAS  Google Scholar 

  45. A. K. Bajpai and A. Giri, Carbohydr. Polym. 53, 271 (2003).

    Article  CAS  Google Scholar 

  46. A. G. Ibrahim, A. Z. Sayed, H. A. El-Wahab, and M. M. Sayah, Am. J. Polym. Sci. Technol. 5, 55 (2019).

    Article  Google Scholar 

  47. D. S. Seeli, S. Dhivya, N. Selvamurugan, and M. Prabaharan, Int. J. Biol. Macromol. 91, 45 (2016).

    Article  CAS  PubMed  Google Scholar 

  48. T. S. Anirudhan and A. M. Mohan, RSC Adv. 4, 12109 (2014).

  49. R. K. Mishra, K. Ramasamy, and A. B. A. Majeed. J. Appl. Polym. Sci. 126, 98 (2012).

    Article  CAS  Google Scholar 

  50. Y. Nakamura, N. Yoshikawa, I. Hiroki, K. Sato, K. Ohtsuki, C. C. Chang, B. L. Upham, and J. E. Trosko, Nutr. Cancer 51, 218 (2005).

    Article  CAS  PubMed  Google Scholar 

  51. Y. Huang, H. Yu, and C. Xiao, Carbohydr. Polym. 69, 774 (2007).

    Article  CAS  Google Scholar 

  52. N. Baït, C. Derail, A. Benaboura, and B. Grasslc, Int. J. Adhes. Adhes. 96 102449 (2020).

    Article  CAS  Google Scholar 

  53. L. I. Xinming and C. U. I. Yingde, Chin. J. Chem. Eng. 16, 640 (2008).

    Article  Google Scholar 

  54. M. U. Ashraf, M. A. Hussain, S. Bashir, M. T. Haseeb, and Z. Hussain, J. Drug Delivery Sci. Technol. 45, 455 (2018).

    Article  CAS  Google Scholar 

  55. E. S. Dragan, D. F. A. Loghin, A. I. Cocarta, and M. Doroftei, React. Funct. Polym. 105, 66 (2016).

    Article  CAS  Google Scholar 

  56. M. Fischer, C. Sperling, and C. Werner, J. Mater. Sci.: Mater. Med. 21, 931 (2010).

    CAS  Google Scholar 

  57. M. Micic and E. Suljovrujic, Eur. Polym. J. 49, 3223 (2013).

    Article  CAS  Google Scholar 

  58. K. I. Block, A. C. Koch, M. N. Mead, P. K. Tothy, R.A. Newman, and C. Gyllenhaal, Int. J. Cancer 123, 1227 (2008).

    Article  CAS  PubMed  Google Scholar 

  59. T. Uchida, S. Sakakibara, Y. Toida, N. Nagareya, N. Yasuda, and K. Matsuyama, Pharm. Pharmacol. Commun. 5, 523(1999).

    Article  CAS  Google Scholar 

  60. I. Bravo-Osuna, C. Vauthier, A. Farabollini, G. F. Palmieri, and G. Ponchel, Biomaterials 28, 2233 (2007).

    Article  CAS  PubMed  Google Scholar 

  61. N. A. Peppas, K. B. Keys, M. Torres-Lugo, and A. M. Lowman, J. Controlled Release 62, 81 (1999).

    Article  CAS  Google Scholar 

  62. L. L. Chaves, A. Silveri, A. C. C. Vieira, D. Ferreira, M. C. Cristiano, D. Paolino, L. D. Marzio, S. C. Lima, S. Reis, B. Sarmento, and C. Celia, Int. J. Biol. Macromol. 133, 1268 (2019).

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Chemistry, Himachal Pradesh University, Shimla, Himachal Pradesh, India

    Baljit Singh,  Rajneesh, Man Mohan &  Divya

  2. Department of Chemistry, Govt. College Una, HP, Affiliation with Himachal Pradesh University, Una, India

    Suresh Kumar

Authors
  1. Baljit Singh
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Suresh Kumar
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Rajneesh
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Man Mohan
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Divya
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Baljit Singh.

Ethics declarations

Authors declare that they have no conflict of interest.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Baljit Singh, Kumar, S., Rajneesh et al. Synthesis and Characterization of Psyllium Polysaccharide–Poly(2-hydroxypropyl methacrylate)−Poly(acrylamide) Hydrogels for Use in Sustained Drug Delivery Applications. Polym. Sci. Ser. B 62, 685–696 (2020). https://doi.org/10.1134/S1560090420330064

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1134/S1560090420330064

Search

Navigation