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Fishing for nucleic acid with a coiled hook
Nature Chemistry ( IF 19.2 ) Pub Date : 2020-12-22 , DOI: 10.1038/s41557-020-00615-9
Jerrin Thomas George 1 , Sarit S Agasti 1
Affiliation  

Site-specific attachment of a programmable motif, such as a synthetic nucleic acid tag, on a target protein can facilitate functional studies of proteins in cells or modulation of protein activity. Now, a small genetically encoded peptide enables the templated incorporation of a peptide nucleic acid tag onto membrane proteins in live cells.

中文翻译:

用盘钩钓核酸

可编程基序(例如合成核酸标签)在靶蛋白上的位点特异性附着可以促进细胞中蛋白质的功能研究或蛋白质活性的调节。现在,一种小的基因编码肽能够将肽核酸标签模板化并入活细胞的膜蛋白上。
更新日期:2020-12-22
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