Site-specific attachment of a programmable motif, such as a synthetic nucleic acid tag, on a target protein can facilitate functional studies of proteins in cells or modulation of protein activity. Now, a small genetically encoded peptide enables the templated incorporation of a peptide nucleic acid tag onto membrane proteins in live cells.
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George, J.T., Agasti, S.S. Fishing for nucleic acid with a coiled hook. Nat. Chem. 13, 5–6 (2021). https://doi.org/10.1038/s41557-020-00615-9
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DOI: https://doi.org/10.1038/s41557-020-00615-9
