A 10-week feeding trial was conducted to investigate the effect of dietary curcumin (CC) on growth antioxidant responses, fatty acid composition, and expression of lipid metabolism-related genes of large yellow croaker fed a high-fat diet (HFD). Four diets (lipid level at 18 %) were formulated with different levels of curcumin (0, 0·02, 0·04 and 0·06 %). The best growth performance was found in the 0·04 % curcumin group, with the body and hepatic lipid levels lower than the control group (0 % CC). The content of TAG, total cholesterol and LDL-cholesterol was the least in the 0·06 % curcumin group. The lowest malondialdehyde and the highest superoxide dismutase, catalase and total antioxidant capacity were observed in the 0·04 % curcumin group. The 0·04 % curcumin group had higher expression of Δ6fad, elovl5 and elovl4 and showed higher hepatic n-6 and n-3 PUFA. Expression of ppara, cpt1, and aco was significantly increased, while expression of srebp1 and fas was dramatically decreased in curcumin groups compared with the control group. Overall, 0·04 % curcumin supplementation could mitigate the negative effects caused by HFD and promote growth via reducing hepatic lipid deposition, improving antioxidant activity and increasing PUFA of large yellow croaker. To conclude, abnormal hepatic lipid deposition was probably due to increased fatty acid oxidation and reduced de novo synthesis of fatty acids.

中文翻译：

---

日粮姜黄素对高脂饲料大黄鱼生长、抗氧化能力、脂肪酸组成及脂代谢相关基因表达的影响

一项为期 10 周的饲养试验旨在研究日粮姜黄素 (CC) 对饲喂高脂饮食 (HFD) 的大黄鱼生长抗氧化反应、脂肪酸组成和脂质代谢相关基因表达的影响。四种日粮（脂质水平为 18 %）用不同水平的姜黄素（0、0·02、0·04 和 0·06 %）配制。0·04 %姜黄素组的生长性能最好，身体和肝脏的脂质水平低于对照组（0 % CC）。0·06%姜黄素组中TAG、总胆固醇和低密度脂蛋白胆固醇的含量最少。0·04%姜黄素组丙二醛最低，超氧化物歧化酶、过氧化氢酶和总抗氧化能力最高。0·04%姜黄素组Δ6fad、elovl5、elovl4表达较高，肝n-6 和n-3 多不饱和脂肪酸。与对照组相比，姜黄素组 ppara、cpt1 和 aco 的表达显着增加，而 srebp1 和 fas 的表达显着降低。总体而言，0·04%的姜黄素补充剂可通过减少肝脏脂质沉积、提高抗氧化活性和增加大黄鱼的PUFA来减轻HFD引起的负面影响并促进生长。总之，肝脏脂质沉积异常可能是由于脂肪酸氧化增加和减少从头脂肪酸的合成。