Magnetic hyperthermia therapy (MHT) is a highly promising therapeutic modality for the treatment of different kinds of cancers and malignant tumors. The therapy is based on the concept that; iron oxide nanoparticles deposited at cancer sites can generate heat when exposed to an alternating current magnetic field or near infrared radiation and consequently destroying only the cancer cells by exploiting their vulnerability to heat. The fact that the treatment is at molecular level and that iron oxide nanoparticles provide more guided focus heating justifies its efficacy over treatment such as surgery, radiation therapy and chemotherapy. Nevertheless, the spread of MHT as the next-generation therapeutics has been shadowed by insufficient heating especially at the in vivo stage. This can be averted by modifying the iron oxide nanoparticle structure. To this end, various attempts have been made by developing a magnetic hybrid nanostructure capable of generating efficient heat. However, the synthesis method for each component (of the magnetic hybrid nanostructure) and the grafting process is now an issue. This has a direct effect on the performance of the magnetic hybrid nanostructure in MHT and other applications. The main objective of this review is to detail out the different materials, methods and characterization techniques that have been used so far in developing magnetic hybrid nanostructure. In view of this, we conducted a comprehensive review and present a road map for developing a magnetic hybrid nanostructure that is capable of generating optimum heat during MHT. We further summarize the various characterization techniques and necessary parameters to study in validating the efficiency of the magnetic hybrid nanostructure. Hopefully, this contribution will serve as a guide to researchers that are willing to evaluate the properties of their magnetic hybrid nanostructure.

中文翻译：

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用于高温的接枝氧化石墨烯的氧化铁的制备

磁热疗法（MHT）是治疗各种癌症和恶性肿瘤的极有前途的治疗方式。该疗法基于以下概念：当暴露于交流磁场或近红外辐射下时，沉积在癌症部位的氧化铁纳米粒子会产生热量，从而通过利用癌细胞的耐热性仅破坏癌细胞。该治疗是在分子水平上进行的，并且氧化铁纳米颗粒提供了更多的引导聚焦加热，这一事实证明了其相对于诸如外科手术，放射疗法和化学疗法的治疗的功效。然而，由于加热不足，尤其是在体内，MHT作为下一代治疗剂的扩散已被掩盖阶段。可以通过修饰氧化铁纳米颗粒结构来避免这种情况。为此，已经通过开发能够产生有效热量的磁性杂化纳米结构进行了各种尝试。但是，（磁性杂化纳米结构的）每种组分的合成方法和接枝过程现在是一个问题。这直接影响了MHT和其他应用中的磁性杂化纳米结构的性能。这篇综述的主要目的是详细介绍迄今为止在开发磁性杂化纳米结构中使用的不同材料，方法和表征技术。有鉴于此，我们进行了全面回顾，并提出了发展磁性杂化纳米结构的路线图，该结构能够在MHT期间产生最佳热量。我们进一步总结了各种表征技术和必要的参数，以研究验证磁性杂化纳米结构的效率。希望这一贡献将为愿意评估其磁性杂化纳米结构特性的研究人员提供指导。