Abstract

The mononuclear complexes [M(Fur)₂(Bpy)(H₂O)] (M = Cu (I), Zn (II)) were prepared by the reactions of copper(II) and zinc(II) acetates with 2-furoic acid (HFur) anion and 2,2'-bipyridine (Bpy) in acetonitrile. A similar reaction with ZnCl₂ used instead of Zn(OAc)₂ · 2H₂O gave the complex [Zn(Fur)₂(Bpy)] (III). The cobalt(II) complex [Co(Fur)₂(Bpy)] (IV) was obtained by the reaction of cobalt trimethylacetate with HFur and Bpy. The structure of mononuclear complexes was determined by X-ray diffraction (CIF files CCDC nos. 1993168 (I), 1993169 (II), 1993170 (III), and 1993171 (IV)). Compounds I, III, and IV were studied for the biological activity in vitro against the nonpathogenic mycobacterial strain Mycolicibacterium smegmatis. It was found that I and III have high biological activity and are promising for further studies for antituberculosis activity.

中文翻译：

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具有2-呋喃酸根阴离子和2,2'-Bpy的单核Cu（II），Zn（II）和Co（II）配合物：合成，结构和生物活性

摘要

单核络合物[M（Fur）₂（Bpy）（H ₂ O）]（M = Cu（I），Zn（II））是通过乙酸铜（II）和乙酸锌（II）与2-的反应制得的糠酸中的糠酸（HFur）阴离子和2,2'-联吡啶（Bpy）。用代替Zn（OAc）₂ ·2H ₂ O的ZnCl _2进行的类似反应得到络合物[Zn（Fur）₂（Bpy）]（III）。通过使三甲基乙酸钴与HFur和Bpy反应获得钴（II）配合物[Co（Fur）₂（Bpy）]（IV）。单核络合物的结构通过X射线衍射确定（CIF文件CCDC No.1993168（I），1993169（II），1993170（III）和1993171（IV））。研究了化合物I，III和IV对非致病性分枝杆菌耻垢分枝杆菌的体外生物活性。已经发现I和III具有高的生物学活性，并有望用于抗结核活性的进一步研究。