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Mononuclear Cu(II), Zn(II), and Co(II) Complexes with 2-Furoate Anions and 2,2'-Bpy: Synthesis, Structure, and Biological Activity

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Abstract

The mononuclear complexes [M(Fur)2(Bpy)(H2O)] (M = Cu (I), Zn (II)) were prepared by the reactions of copper(II) and zinc(II) acetates with 2-furoic acid (HFur) anion and 2,2'-bipyridine (Bpy) in acetonitrile. A similar reaction with ZnCl2 used instead of Zn(OAc)2 · 2H2O gave the complex [Zn(Fur)2(Bpy)] (III). The cobalt(II) complex [Co(Fur)2(Bpy)] (IV) was obtained by the reaction of cobalt trimethylacetate with HFur and Bpy. The structure of mononuclear complexes was determined by X-ray diffraction (CIF files CCDC nos. 1993168 (I), 1993169 (II), 1993170 (III), and 1993171 (IV)). Compounds I, III, and IV were studied for the biological activity in vitro against the nonpathogenic mycobacterial strain Mycolicibacterium smegmatis. It was found that I and III have high biological activity and are promising for further studies for antituberculosis activity.

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ACKNOWLEDGMENTS

The X-ray diffraction studies were supported by the Ministry of Science and Higher Education of the Russian Federation and performed using research equipment of the Center of Investigation of Molecular Structure of the Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences. Elemental analysis and IR spectroscopy were carried out using research equipment of the Center for Collective Use of the Physical Investigation Methods, Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences, which was supported by the State Assignment for the Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences, in the field of fundamental research.

Funding

This work was supported by the Russian Science Foundation (project 20-13-00061).

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Authors and Affiliations

  1. Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences, 119991, Moscow, Russia

    I. A. Lutsenko, D. S. Yambulatov, M. A. Kiskin, A. A. Sidorov & I. L. Eremenko

  2. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, 119991, Moscow, Russia

    Yu. V. Nelyubina & P. V. Primakov

  3. Vavilov Institute of General Genetics, Russian Academy of Sciences, 119991, Moscow, Russia

    O. B. Bekker

Authors
  1. I. A. Lutsenko
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  2. D. S. Yambulatov
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  3. M. A. Kiskin
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  4. Yu. V. Nelyubina
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  5. P. V. Primakov
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  6. O. B. Bekker
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  7. A. A. Sidorov
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  8. I. L. Eremenko
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Correspondence to I. A. Lutsenko.

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Translated by Z. Svitanko

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Lutsenko, I.A., Yambulatov, D.S., Kiskin, M.A. et al. Mononuclear Cu(II), Zn(II), and Co(II) Complexes with 2-Furoate Anions and 2,2'-Bpy: Synthesis, Structure, and Biological Activity. Russ J Coord Chem 46, 787–794 (2020). https://doi.org/10.1134/S1070328420120040

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  • DOI: https://doi.org/10.1134/S1070328420120040

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