Abstract

Myrcauones A–D (1–4), four new phloroglucinol–terpene adducts were isolated from the leaves of Myrciaria cauliflora. Their structures with absolute configurations were elucidated by combination of spectroscopic analysis, single crystal X-ray diffraction, and electronic circular dichroism (ECD) calculations. Compound 1 was a rearranged isobutylphloroglucinol–pinene adduct featuring an unusual 2,3,4,4a,10,11-hexahydro-1H-3,11a-methanodibenzo[b,f]oxepin backbone. Compound 4 showed moderate antibacterial activity against Gram-positive bacteria including multiresistant strains.

Graphic Abstract

中文翻译：

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菜花Myrciaria cauliflora叶片中的四种新的间苯三酚-萜烯加合物

摘要

Myrcauones A-d（1 - 4），四个新的间苯三酚，萜烯加合物从叶分离Myrciaria cauliflora。结合光谱分析，单晶X射线衍射和电子圆二色性（ECD）计算，阐明了它们具有绝对构型的结构。化合物1是重排的异丁基间苯三酚-pine烯加合物，具有不寻常的2,3,4,4a，10,11-六氢-1 H -3,11a-甲基二苯并[ b，f ] oxepin主链。化合物4对包括多重耐药菌株在内的革兰氏阳性细菌显示出中等的抗菌活性。

图形摘要