The adsorption of ligands to macromolecules is theoretically investigated in this work in the case when the structure of the adsorption center changes when a ligand is bound to the macromolecule. In this case, the adsorption kinetics is described by a set of two nonlinear differential equations. This consideration results in such properties that the adsorption center acquires the multiplicity of stationary states (including the bistable states), trigger and hysteresis behavior. It is shown that taking into account the deformation of the adsorption center results in an S-shaped adsorption isotherm.

中文翻译：

---

吸附的自洽描述和吸附中心结构的变化

在配体结合到大分子上而吸附中心的结构发生变化的情况下，理论上研究了配体对大分子的吸附。在这种情况下，吸附动力学由一组两个非线性微分方程描述。这种考虑导致了这样的性质，即吸附中心获得了多个稳态（包括双稳态），触发和滞后行为。结果表明，考虑到吸附中心的变形会导致S形吸附等温线。