Skip to main content
SpringerLink
Log in

Self-Consistent Description of Adsorption and Changes in the Adsorption Center Structure

  • Published:
Journal of Contemporary Physics (Armenian Academy of Sciences) Aims and scope

Abstract

The adsorption of ligands to macromolecules is theoretically investigated in this work in the case when the structure of the adsorption center changes when a ligand is bound to the macromolecule. In this case, the adsorption kinetics is described by a set of two nonlinear differential equations. This consideration results in such properties that the adsorption center acquires the multiplicity of stationary states (including the bistable states), trigger and hysteresis behavior. It is shown that taking into account the deformation of the adsorption center results in an S-shaped adsorption isotherm.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Nechipurenko, Yu.D., Actual problems of biological physics and chemistry, 2016, vol. 1, p. 204.

    Google Scholar 

  2. Bloomfield, V.A., Crothers, D.M., and Tinoco, I., Nucleic acids: structures, properties and functions, University Science Books, Sausalito, CA. 2000.

    Google Scholar 

  3. Arakelyan, V.B., Harutyunyan, S.V., Andriasyan, V., and Arakelyan. H.V., J. Biomol. Struct. Dyn., 2012, vol. 30, p. 217.

    Article  Google Scholar 

  4. Arakelyan, V.B., Haroutiunian, S.G., Abgaryan, G.A., Arakelyan, H.V., and Haroutunyan, T.S., J. Biomol. Struct. Dyn., 2004, vol. 22, p. 245.

    Article  Google Scholar 

  5. Gaididei, Yu.B., Magura, I.S., Pivovarova, N.V., Harkyanen, V.N., and Chinarov, V.A., Biol. Membranes (Biol. Membrany), 1991, vol. 8, p. 648.

    Google Scholar 

  6. Bratus', A.S., Novozhilov, A.S., and Platonov, A.P., Dinamicheskiye sistemy i modeli biologii (Dynamic systems and models of biology), Fizmatlit, 2010.

    Google Scholar 

  7. Kharkyanen, V.N., Yesylevskyy, S.O., Berezetskaya, N.M., Boiteux, C., and Ramseyer, Ch., Biopolymers and Cell., 2009, vol. 25, p. 476.

    Article  Google Scholar 

  8. Nechipurenko, Y.D., Mikheikin, A.L., Streltsov, S.A., Zasedatelev, A.S., and Nabiev, I.R., J. Biomol. Struct. Dyn., 2001, vol. 18, p. 703.

    Article  Google Scholar 

  9. Nechipurenko, Yu.D., Analiz svyazyvaniya biologicheski aktivnykh soyedineniy s nukleinovymi kislotami (Analysis of the binding of biologically active compounds to nucleic acids), Izhevsk IKI, Moscow, 2015.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Yerevan State University, Yerevan, Armenia

    V. B. Arakelyan

  2. Yerevan State Medical University Named After Mkhitar Heratsi, Yerevan, Armenia

    S. V. Harutyunyan & S. P. Kocharyan

Authors
  1. V. B. Arakelyan
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. S. V. Harutyunyan
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. S. P. Kocharyan
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to V. B. Arakelyan.

Additional information

Russian Text © The Author(s), 2019, published in Izvestiya Natsional'noi Akademii Nauk Armenii, Fizika, 2019, Vol. 54, No. 4, pp. 537–548.

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Arakelyan, V.B., Harutyunyan, S.V. & Kocharyan, S.P. Self-Consistent Description of Adsorption and Changes in the Adsorption Center Structure. J. Contemp. Phys. 54, 394–402 (2019). https://doi.org/10.3103/s1068337219040108

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.3103/s1068337219040108

Keywords

Search

Navigation