The content of damaged 8-hydroxy-2-deoxyguanosine nitrogenous bases in the blood DNA of healthy donors and patients with epidermolysis bullosa after exposure to an alternating magnetic field of 550 ± 30 A/m in the frequency range from 3 to 60 Hz in vitro was determined using an enzyme immunoassay. The degree of oxidative DNA damage in epidermolysis bullosa was almost twice as high as in healthy donors. It was shown that there was a significant increase in the level of 8-oxoguanine in the DNA of both groups after the magnetic field treatment, which depended in a complex way on the frequency. The resulting effect is explained by the generation of reactive oxygen species under the influence of a magnetic field and the disruption of DNA repair processes.

中文翻译：

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交变磁场作用下DNA的氧化损伤

健康供体和大疱性表皮松解患者在体外频率为3至60 Hz的550±30 A / m交变后血液DNA中受损的8-羟基-2-脱氧鸟嘌呤氮基含量使用酶免疫测定法测定。大疱表皮松解中氧化性DNA损伤的程度几乎是健康供体的两倍。结果表明，磁场处理后，两组DNA中的8-氧代鸟嘌呤含量均显着增加，这主要取决于频率。通过在磁场和DNA修复过程中断的影响下产生活性氧来解释产生的效果。