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Effect of Original Peptide Derivatives of Galantamine on Passive Avoidance in Mice
Bulletin of Experimental Biology and Medicine ( IF 0.9 ) Pub Date : 2020-12-01 , DOI: 10.1007/s10517-020-05032-z
I I Kostadinova 1 , N D Danchev 1 , L T Vezenkov 2 , D S Tsekova 2 , V V Rozhanets 3
Affiliation  

The effect of original peptide derivatives of galantamine on scopolamine-induced memory impairment in mice was assessed using the passive avoidance test over 12 days. It was found that some galantamine derivatives administered in a dose of 1/20LD50 improved the memory in experimental mice, especially on days 5-12 of the experiment.

中文翻译:

加兰他敏原始肽​​衍生物对小鼠被动回避的影响

加兰他敏的原始肽衍生物对东莨菪碱诱导的小鼠记忆障碍的影响使用被动回避测试进行了 12 天的评估。发现以 1/20LD50 的剂量给药的一些加兰他敏衍生物改善了实验小鼠的记忆力,尤其是在实验的第 5-12 天。
更新日期:2020-12-01
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