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Effect of Original Peptide Derivatives of Galantamine on Passive Avoidance in Mice

  • PHARMACOLOGY AND TOXICOLOGY
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Bulletin of Experimental Biology and Medicine Aims and scope

The effect of original peptide derivatives of galantamine on scopolamine-induced memory impairment in mice was assessed using the passive avoidance test over 12 days. It was found that some galantamine derivatives administered in a dose of 1/20LD50 improved the memory in experimental mice, especially on days 5-12 of the experiment.

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Authors and Affiliations

  1. Department of Pharmacology, Pharmacotherapy, and Toxicology, Faculty of Pharmacy, Medical University of Sofia, Sofia, Bulgaria

    I. I. Kostadinova & N. D. Danchev

  2. Department of Organic Chemistry, University of Chemical Technology and Metallurgy, Sofia, Bulgaria

    L. T. Vezenkov & D. S. Tsekova

  3. Laboratory of Analytical Toxicology, National Scientific Centre of Narcology — Affiliated Branch of V. P. Serbsky National Medical Research Centre of Psychiatry and Narcology, Ministry of Health of the Russian Federation, Moscow, Russia

    V. V. Rozhanets

Authors
  1. I. I. Kostadinova
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  2. N. D. Danchev
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  3. L. T. Vezenkov
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  4. D. S. Tsekova
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  5. V. V. Rozhanets
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Corresponding author

Correspondence to I. I. Kostadinova.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 170, No. 8, pp. 165-167, August, 2020

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Kostadinova, I.I., Danchev, N.D., Vezenkov, L.T. et al. Effect of Original Peptide Derivatives of Galantamine on Passive Avoidance in Mice. Bull Exp Biol Med 170, 200–202 (2020). https://doi.org/10.1007/s10517-020-05032-z

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  • DOI: https://doi.org/10.1007/s10517-020-05032-z

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