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Biological Activity of Some Heterocyclic Compounds Based on Polyol Acetals and their Derivatives
Pharmaceutical Chemistry Journal ( IF 0.8 ) Pub Date : 2020-11-29 , DOI: 10.1007/s11094-020-02295-8
G. Z. Raskil’dina , U. Sh. Kuz’mina , Yu. G. Borisova , Yu. V. Vakhitova , S. S. Zlotskii

The biological activity of cyclic acetals (penta- and dipentaerythritol, ethriol, and diglycerol) and 5-ethyl-5-hydroxymethyl-1,3-dioxane esters was studied in vitro. The cytotoxic properties of 5-ethyl-5-hydroxymethyl-1,3-dioxane esters were established on HEK293 and SH-SY5Y cell lines. Potential antioxidant properties of 7,11,18,21-tetraoxaspiro-5,2,2,5-heneicosane, 2-[(5-ethyl-5-hydroxymethyl)-1,3-dioxan-2-yl]phenol, 4.4-[oxydi(methylene)]-bis-2-diisopropyl-1,3-dioxolane, 4,4_-[oxydi(methylene)]-bis-1,3-dioxolane, (5-ethyl-1,3-dioxan-5-yl)methyl-2-methyl acrylate, and bis(5-ethyl-1,3-dioxan-5-yl)methyl maleate were established in vitro using an oxidative stress model.

中文翻译:

一些基于多元醇缩醛及其衍生物的杂环化合物的生物活性

体外研究了环状缩醛(五-和二季戊四醇、乙三醇和双甘油)和 5-乙基-5-羟甲基-1,3-二恶烷酯的生物活性。在 HEK293 和 SH-SY5Y 细胞系上建立了 5-乙基-5-羟甲基-1,3-二恶烷酯的细胞毒性特性。7,11,18,21-tetraoxaspiro-5,2,2,5-heneicosane, 2-[(5-ethyl-5-hydroxymethyl)-1,3-dioxan-2-yl]phenol, 4.4 的潜在抗氧化性能-[oxydi(methylene)]-bis-2-diisopropyl-1,3-dioxolane, 4,4_-[oxydi(methylene)]-bis-1,3-dioxolane, (5-ethyl-1,3-dioxan-使用氧化应激模型在体外建立了 5-yl)methyl-2-methyl 丙烯酸和双 (5-ethyl-1,3-dioxan-5-yl)methylmaleate。
更新日期:2020-11-29
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