The biological activity of cyclic acetals (penta- and dipentaerythritol, ethriol, and diglycerol) and 5-ethyl-5-hydroxymethyl-1,3-dioxane esters was studied in vitro. The cytotoxic properties of 5-ethyl-5-hydroxymethyl-1,3-dioxane esters were established on HEK293 and SH-SY5Y cell lines. Potential antioxidant properties of 7,11,18,21-tetraoxaspiro-5,2,2,5-heneicosane, 2-[(5-ethyl-5-hydroxymethyl)-1,3-dioxan-2-yl]phenol, 4.4-[oxydi(methylene)]-bis-2-diisopropyl-1,3-dioxolane, 4,4_-[oxydi(methylene)]-bis-1,3-dioxolane, (5-ethyl-1,3-dioxan-5-yl)methyl-2-methyl acrylate, and bis(5-ethyl-1,3-dioxan-5-yl)methyl maleate were established in vitro using an oxidative stress model.
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Acknowledgments
The studies were sponsored by the RFBR competition mol ev a (Eureka! Idea), contract No. 19-33-80002\19 of Dec. 7, 2018, and according to the plan of State Task to IBG, UfSC, RAS (No. AA-AA-F16-116020350033-8).
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 54, No. 9, pp. 27 – 31, September, 2020.
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Raskil’dina, G.Z., Kuz’mina, U.S., Borisova, Y.G. et al. Biological Activity of Some Heterocyclic Compounds Based on Polyol Acetals and their Derivatives. Pharm Chem J 54, 909–913 (2020). https://doi.org/10.1007/s11094-020-02295-8
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DOI: https://doi.org/10.1007/s11094-020-02295-8