Direct synthesis of 2,3,5-trisubstituted pyrroles via copper-mediated one-pot multicomponent reaction,Organic & Biomolecular Chemistry

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Direct synthesis of 2,3,5-trisubstituted pyrroles via copper-mediated one-pot multicomponent reaction
Organic & Biomolecular Chemistry ( IF 2.9 ) Pub Date : 2020-11-23 , DOI: 10.1039/d0ob01952f
Jian-Ping He ₁ , Zhen-Zhen Zhan , Nan Luo , Ming-Ming Zhang , Guo-Sheng Huang

Affiliation

We have developed a copper-mediated one-pot synthesis of 2,3,5-trisubstituted pyrroles from 1,3-dicarbonyl compounds and acrylates using ammonium acetate as a nitrogen source. The reaction achieves C–C and C–N bond formation and provides an efficient approach to access highly functionalized pyrroles without further raw material preparation. This method is operationally simple, compatible with a wide range of functional groups, and provides the target products in moderate to good yields.

中文翻译：

铜介导的一锅多组分反应直接合成2,3,5-三取代吡咯

我们开发了一种以乙酸铵为氮源，由 1,3-二羰基化合物和丙烯酸酯合成 2,3,5-三取代吡咯的铜介导的一锅法合成方法。该反应实现了 C-C 和 C-N 键的形成，并提供了一种无需进一步制备原料即可获得高度官能化吡咯的有效方法。该方法操作简单，与广泛的官能团兼容，并以中等至良好的收率提供目标产物。

更新日期：2020-11-27

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