Issue 48, 2020
From the journal:

Organic & Biomolecular Chemistry

Direct synthesis of 2,3,5-trisubstituted pyrroles via copper-mediated one-pot multicomponent reaction†

Jian-Ping He,a   Zhen-Zhen Zhan,a   Nan Luo,a   Ming-Ming Zhanga  and  Guo-Sheng Huang ORCID logo *a  

* Corresponding authors

a State Key Laboratory of Applied Organic Chemistry, Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province, Department of Chemistry, Lanzhou University, Lanzhou 730000, China
E-mail: hgs@lzu.edu.cn

Abstract

We have developed a copper-mediated one-pot synthesis of 2,3,5-trisubstituted pyrroles from 1,3-dicarbonyl compounds and acrylates using ammonium acetate as a nitrogen source. The reaction achieves C–C and C–N bond formation and provides an efficient approach to access highly functionalized pyrroles without further raw material preparation. This method is operationally simple, compatible with a wide range of functional groups, and provides the target products in moderate to good yields.

Graphical abstract: Direct synthesis of 2,3,5-trisubstituted pyrroles via copper-mediated one-pot multicomponent reaction

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Article information

DOI
https://doi.org/10.1039/D0OB01952F
Article type
Paper
Submitted
23 Sep 2020
Accepted
20 Nov 2020
First published
23 Nov 2020

Org. Biomol. Chem., 2020,18, 9831-9835

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Direct synthesis of 2,3,5-trisubstituted pyrroles via copper-mediated one-pot multicomponent reaction

J. He, Z. Zhan, N. Luo, M. Zhang and G. Huang, Org. Biomol. Chem., 2020, 18, 9831 DOI: 10.1039/D0OB01952F

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