By employment of a flexible benzoimidazole-type ligand of 1-(2-(1H-benzoimidazol-1-yl)ethyl)-1H-benzoimidazole (beb), two coordination polymers (CPs) of Zn(II) and Co(II) namely, {[Co(beb)(dmglut)]}_n (1) and {Zn₂(beb)₂(hipt)₂(H₂O)_1.5(MeOH)}]_n (2) have been produced in the existence of distinct dicarboxylate ligands and metal ions. The measurements of luminescence reveal that the Zn(II)-containing complex 2 can determine 2,4,6-trinitrophenol (TNP) in DMF which possesses high selectivity and sensitivity. For the treatment of Alzheimer’s disease, complexes 1 and 2 were synthesized as above. Their treatment activity on the Alzheimer’s disease was evaluated, and the specific mechanism was investigated as well. Western blot was used to detect the accumulation of Amyloid protein in neurons. Then, the real time RT-PCR was implemented to assess autophagy related genes expression levels.

通过使用1-（2-（1H-苯并咪唑-1-基）乙基）-1H-苯并咪唑的柔性苯并咪唑型配体（beb），可以得到Zn（II）和Co（II）的两个配位聚合物（CP）即，在存在的情况下产生了{[Co（beb）（dmglut）]} _n（1）和{Zn ₂（beb）₂（hipt）₂（H ₂ O）_1.5（MeOH）} _n（2）。不同的二羧酸盐配体和金属离子 发光的测量结果表明，含Zn（II）的配合物2可以确定DMF中的2,4,6-三硝基苯酚（TNP），它具有很高的选择性和灵敏度。用于治疗阿尔茨海默氏病，复合物1如上所述合成2和1。评估了它们对阿尔茨海默氏病的治疗活性，并研究了其具体机制。Western blot用于检测神经元中淀粉样蛋白的积累。然后，实施实时RT-PCR以评估自噬相关基因的表达水平。