A novel mechanism enabling selective peptide elongation by coupling α-amino acids over other potentially competing prebiotic amines under acidic aqueous condition is suggested. It proceeds via the generation of a carboxylic acid anhydride intermediate with subsequent intramolecular formation of the amide bond.

中文翻译：

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通过水中α-氨基酸的选择性偶联形成pH依赖性肽键

提出了一种新的机制，该机制通过在酸性水溶液条件下将α-氨基酸偶联到其他可能竞争的益生元胺上来实现选择性的肽延长。它通过生成羧酸酐中间体进行，随后在分子内形成酰胺键。