Issue 1, 2021

pH-Dependent peptide bond formation by the selective coupling of α-amino acids in water

Abstract

A novel mechanism enabling selective peptide elongation by coupling α-amino acids over other potentially competing prebiotic amines under acidic aqueous condition is suggested. It proceeds via the generation of a carboxylic acid anhydride intermediate with subsequent intramolecular formation of the amide bond.

Graphical abstract: pH-Dependent peptide bond formation by the selective coupling of α-amino acids in water

Supplementary files

Article information

Article type
Communication
Submitted
07 Sep 2020
Accepted
20 Nov 2020
First published
20 Nov 2020
This article is Open Access
Creative Commons BY license

Chem. Commun., 2021,57, 73-76

pH-Dependent peptide bond formation by the selective coupling of α-amino acids in water

L. Wu, Z. Liu and J. D. Sutherland, Chem. Commun., 2021, 57, 73 DOI: 10.1039/D0CC06042A

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements