This study evaluated the effect of Mucuna pruriens (MP) administration on neuroinflammation and behavioral and murinometric parameters in obese rats. Proximate composition, oligosaccharide and phenolic compound profile of MP were determined. Wistar adult male rats were randomized into healthy (HG) and obese group (OG). The HG consumed a control chow diet while OG consumed a cafeteria diet for eight weeks. Then, they were subdivided into: Healthy (HG); Healthy with MP administration (HGMP); Obese (OG); Obese with MP administration (OGMP), with the consumption of the respective diets remaining for another eight weeks, in addition to gavage with MP extract to supplemented groups (750 mg/kg weight). MP presented a composition rich in proteins and phenolic compounds, especially catechin, in addition to 1-kestose and levodopa. Supplementation reduced food intake, body weight, and thoracic and abdominal circumferences in obese rats. MP showed anxiolytic and antidepressant effects and reduced morphological damage and expression of interleukin 6 in the hippocampus of obese rats. MP treatment showed satietogenic, slimming, anxiolytic and antidepressant effects, besides to minimizing hippocampal neuroinflammation in obese rats. Our results demonstrated the potential anti-obesity of MP which are probably related to the high content of bioactive compounds present in this plant extract.

中文翻译：

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Mucuna pruriens 给药可最大限度地减少肥胖大鼠的神经炎症并显示抗焦虑、抗抑郁和减肥效果

本研究评估了黧豆粉 (MP) 给药对肥胖大鼠的神经炎症以及行为和 murinometric 参数的影响。确定了 MP 的近似组成、低聚糖和酚类化合物谱。Wistar 成年雄性大鼠随机分为健康组（HG）和肥胖组（OG）。HG 食用对照食物，而 OG 食用自助餐厅饮食八周。然后，它们被细分为：健康（HG）；健康与 MP 管理 (HGMP); 肥胖 (OG); MP 给药 (OGMP) 肥胖，除了用 MP 提取物灌胃至补充组 (750 毫克/千克体重) 外，各自饮食的消耗量再持续八周。除了 1-酮糖和左旋多巴之外，MP 还提供了富含蛋白质和酚类化合物的组合物，尤其是儿茶素。补充剂减少了肥胖大鼠的食物摄入量、体重以及胸腹围。MP 显示出抗焦虑和抗抑郁作用，并减少肥胖大鼠海马体的形态学损伤和白细胞介素 6 的表达。MP 治疗显示出饱腹感、减肥、抗焦虑和抗抑郁作用，除了最大限度地减少肥胖大鼠的海马神经炎症。我们的结果表明 MP 具有潜在的抗肥胖作用，这可能与该植物提取物中存在的高含量生物活性化合物有关。除了减少肥胖大鼠的海马神经炎症外，还具有抗焦虑和抗抑郁作用。我们的结果表明 MP 具有潜在的抗肥胖作用，这可能与该植物提取物中存在的高含量生物活性化合物有关。除了减少肥胖大鼠的海马神经炎症外，还具有抗焦虑和抗抑郁作用。我们的结果表明 MP 具有潜在的抗肥胖作用，这可能与该植物提取物中存在的高含量生物活性化合物有关。