An artificial intelligence process of immunoassay for multiple biomarkers based on logic gates,Analyst

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An artificial intelligence process of immunoassay for multiple biomarkers based on logic gates
Analyst ( IF 3.6 ) Pub Date : 2020-11-09 , DOI: 10.1039/d0an01844a
Wenjie Liu _{1,

2,

3,

4} , Jihong Liu _{3,

4,

5,

6,

7} , Ao Huang _{1,

2,

3,

4} , Shuo Shi _{1,

2,

3,

4} , Tianming Yao _{1,

2,

3,

4}

Affiliation

We present a universal platform to synchronously analyze the possible existing state of two protein biomarkers. This platform is based on the integration of three logic gates: NAND, OR and NOT. These logic gates were constructed by the principle of immune recognition and fluorescence quenching between fluorescein labelled antibodies/antigens and antibody-conjugated graphene oxide (GO). An artificial intelligence (AI) protein analysis process was designed by us and accordingly a small program was written in JAVA. This protein analysis process with its JAVA code may be applied to give logic judgments on the possible existing state of two protein components. We expect that our fundamental research on multiple biomarker analysis can provide potential application in AI-assisted medical diagnosis with the interface for remote medical treatment.

中文翻译：

基于逻辑门的多种生物标志物免疫测定的人工智能过程

我们提出了一个通用平台，以同步分析两种蛋白质生物标志物的可能存在状态。该平台基于三个逻辑门的集成：NAND，OR和NOT。这些逻辑门是通过免疫识别和荧光素标记的抗体/抗原与抗体偶联的氧化石墨烯（GO）之间的荧光猝灭原理构建的。我们设计了一个人工智能（AI）蛋白质分析过程，因此用JAVA编写了一个小程序。具有其JAVA代码的蛋白质分析过程可用于对两种蛋白质成分可能存在的状态进行逻辑判断。我们希望我们对多种生物标志物分析的基础研究可以通过远程医疗接口在AI辅助医学诊断中提供潜在的应用。

更新日期：2020-11-25

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