Issue 3, 2021

An artificial intelligence process of immunoassay for multiple biomarkers based on logic gates

Abstract

We present a universal platform to synchronously analyze the possible existing state of two protein biomarkers. This platform is based on the integration of three logic gates: NAND, OR and NOT. These logic gates were constructed by the principle of immune recognition and fluorescence quenching between fluorescein labelled antibodies/antigens and antibody-conjugated graphene oxide (GO). An artificial intelligence (AI) protein analysis process was designed by us and accordingly a small program was written in JAVA. This protein analysis process with its JAVA code may be applied to give logic judgments on the possible existing state of two protein components. We expect that our fundamental research on multiple biomarker analysis can provide potential application in AI-assisted medical diagnosis with the interface for remote medical treatment.

Graphical abstract: An artificial intelligence process of immunoassay for multiple biomarkers based on logic gates

Supplementary files

Article information

Article type
Paper
Submitted
14 Sep 2020
Accepted
08 Nov 2020
First published
09 Nov 2020

Analyst, 2021,146, 889-895

An artificial intelligence process of immunoassay for multiple biomarkers based on logic gates

W. Liu, J. Liu, A. Huang, S. Shi and T. Yao, Analyst, 2021, 146, 889 DOI: 10.1039/D0AN01844A

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