Abstract

The perspectives of using γ-mercaptopropyltrimethoxysilane as a precursor for creating multifunctional composite nanoparticles (CNPs) with a rodlike gold core and an organosilica shell have been analyzed. It is shown that the presence of thiol groups, which are capable of specific interactions with metal ions and atoms, in the shell makes it possible to “directly” (i.e., without any additional modification) load rather large amounts of an anticancer drug, cisplatin, into it. In addition, preliminary data have been obtained that indicate the possibility of nitrosation of the SH-groups of the shells, which is very important from the viewpoint of creating container CNPs for NO, with such containers providing not only its delivery to tumors, but also its controlled release under the action of laser radiation.

中文翻译：

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具有有机硅壳的金纳米棒作为创建多功能纳米结构的平台

摘要

分析了使用γ-巯基丙基三甲氧基硅烷作为前体生成具有棒状金核和有机硅壳的多功能复合纳米粒子（CNP）的观点。结果表明，壳中能够与金属离子和原子发生特定相互作用的巯基的存在，使得“直接”（即不作任何其他修饰）负载相当大量的抗癌药物顺铂成为可能。 ， 进去。另外，已经获得表明壳的SH-基团亚硝化的初步数据，从创建用于NO的容器CNP的观点来看，这是非常重要的，这种容器不仅提供其向肿瘤的递送，而且还提供其向肿瘤的递送。其在激光辐射作用下的受控释放。