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Gold Nanorods with Organosilica Shells as a Platform for Creating Multifunctional Nanostructures

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Abstract

The perspectives of using γ-mercaptopropyltrimethoxysilane as a precursor for creating multifunctional composite nanoparticles (CNPs) with a rodlike gold core and an organosilica shell have been analyzed. It is shown that the presence of thiol groups, which are capable of specific interactions with metal ions and atoms, in the shell makes it possible to “directly” (i.e., without any additional modification) load rather large amounts of an anticancer drug, cisplatin, into it. In addition, preliminary data have been obtained that indicate the possibility of nitrosation of the SH-groups of the shells, which is very important from the viewpoint of creating container CNPs for NO, with such containers providing not only its delivery to tumors, but also its controlled release under the action of laser radiation.

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Notes

  1. Note that the sorption values calculated form the absorption spectroscopy data are substantially larger. Apparently, this is due to the presence of some amount of SH-SiO1.5 particles, which have been formed in the course of the shell synthesis and can also sorb cisplatin, in the dispersion.

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ACKNOWLEDGMENTS

We are very grateful to P.R. Kazanskii (Center for Collective Use “Microanalysis,” Moscow) for the electron microscopic and elemental analysis of CNPs, and A.V. Zaitseva (Frumkin Institute of Physical Chemistry and Electrochemistry, Russian Academy of Sciences) for the AFM examination of CNPs.

Funding

The work was performed within the framework of the order of the Ministry of Science and Higher Education of the Russian Federation and was supported by the Russian Foundation for Basic Reseach (project no. 20-33-90266).

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Authors and Affiliations

  1. Frumkin Institute of Physical Chemistry and Electrochemistry, Russian Academy of Sciences, 119071, Moscow, Russia

    N. A. Salavatov, O. V. Dement’eva & V. M. Rudoy

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  1. N. A. Salavatov
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  2. O. V. Dement’eva
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  3. V. M. Rudoy
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Correspondence to O. V. Dement’eva.

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Salavatov, N.A., Dement’eva, O.V. & Rudoy, V.M. Gold Nanorods with Organosilica Shells as a Platform for Creating Multifunctional Nanostructures. Colloid J 82, 713–718 (2020). https://doi.org/10.1134/S1061933X20060125

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