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Visible-light induced copper(I)-catalyzed oxidative cyclization of o-aminobenzamides with methanol and ethanol via HAT
Organic & Biomolecular Chemistry ( IF 2.9 ) Pub Date : 2020-11-13 , DOI: 10.1039/d0ob02234a
Mandapati Bhargava Reddy 1 , Kesavan Prasanth , Ramasamy Anandhan
Affiliation  

The use of the in situ generated ligand–copper superoxo complex absorbing light energy to activate the alpha C(sp3)–H of MeOH and EtOH via the hydrogen atom transfer (HAT) process for the synthesis of quinazolinones by oxidative cyclization of alcohols with o-aminobenzamide has been investigated. The synthetic utility of this protocol offers an efficient synthesis of a quinazolinone intermediate for erlotinb (anti-cancer agent) and 30 examples were reported.

中文翻译:

可见光诱导铜 (I) 催化的邻氨基苯甲酰胺与甲醇和乙醇通过 HAT 的氧化环化

使用原位产生的配体-铜超氧络合物吸收光能,通过氢原子转移 (HAT) 过程激活MeOH 和 EtOH的 α C(sp 3 )-H,通过醇的氧化环化合成喹唑啉酮研究了氨基苯甲酰胺。该协议的合成效用提供了一种用于 erlotinb(抗癌剂)的喹唑啉酮中间体的有效合成,并报告了 30 个示例。
更新日期:2020-11-23
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