Visible-light induced copper(I)-catalyzed oxidative cyclization of o-aminobenzamides with methanol and ethanol via HAT,Organic & Biomolecular Chemistry

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Visible-light induced copper(I)-catalyzed oxidative cyclization of o-aminobenzamides with methanol and ethanol via HAT
Organic & Biomolecular Chemistry ( IF 2.9 ) Pub Date : 2020-11-13 , DOI: 10.1039/d0ob02234a
Mandapati Bhargava Reddy ₁ , Kesavan Prasanth , Ramasamy Anandhan

Affiliation

The use of the in situ generated ligand–copper superoxo complex absorbing light energy to activate the alpha C(sp³)–H of MeOH and EtOH via the hydrogen atom transfer (HAT) process for the synthesis of quinazolinones by oxidative cyclization of alcohols with o-aminobenzamide has been investigated. The synthetic utility of this protocol offers an efficient synthesis of a quinazolinone intermediate for erlotinb (anti-cancer agent) and 30 examples were reported.

中文翻译：

可见光诱导铜 (I) 催化的邻氨基苯甲酰胺与甲醇和乙醇通过 HAT 的氧化环化

使用原位产生的配体-铜超氧络合物吸收光能，通过氢原子转移 (HAT) 过程激活MeOH 和 EtOH的 α C(sp ³ )-H，通过醇的氧化环化合成喹唑啉酮研究了邻氨基苯甲酰胺。该协议的合成效用提供了一种用于 erlotinb（抗癌剂）的喹唑啉酮中间体的有效合成，并报告了 30 个示例。

更新日期：2020-11-23

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