Issue 47, 2020
From the journal:

Organic & Biomolecular Chemistry

Visible-light induced copper(i)-catalyzed oxidative cyclization of o-aminobenzamides with methanol and ethanol via HAT†

Mandapati Bhargava Reddy, ORCID logo a   Kesavan Prasantha  and  Ramasamy Anandhan ORCID logo *a  

* Corresponding authors

a Department of Organic Chemistry University of Madras, Chennai-025, Tamilnadu, India
E-mail: ananthanramasamy@gmail.com

Abstract

The use of the in situ generated ligand–copper superoxo complex absorbing light energy to activate the alpha C(sp3)–H of MeOH and EtOH via the hydrogen atom transfer (HAT) process for the synthesis of quinazolinones by oxidative cyclization of alcohols with o-aminobenzamide has been investigated. The synthetic utility of this protocol offers an efficient synthesis of a quinazolinone intermediate for erlotinb (anti-cancer agent) and 30 examples were reported.

Graphical abstract: Visible-light induced copper(i)-catalyzed oxidative cyclization of o-aminobenzamides with methanol and ethanol via HAT

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/D0OB02234A
Article type
Communication
Submitted
10 Nov 2020
Accepted
13 Nov 2020
First published
13 Nov 2020

Org. Biomol. Chem., 2020,18, 9601-9605

Permissions

Request permissions

Visible-light induced copper(I)-catalyzed oxidative cyclization of o-aminobenzamides with methanol and ethanol via HAT

M. Bhargava Reddy, K. Prasanth and R. Anandhan, Org. Biomol. Chem., 2020, 18, 9601 DOI: 10.1039/D0OB02234A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements