Cancer is a disorder that results in abnormal and irregular proliferation of cells in the organ or tissue of the body. In Turkey flora, there are many medicinal plants that have great therapeutic importance. Rhaponticoides iconiensis is endemic to Turkey. In the present study, the methanol extracts and sub-extracts of leafy stem and flowers of R. iconiensis were evaluated for cytotoxic activity against Colo 205, A549, HepG2, MCF7 and Beas-2b cell lines by MTT method. The compounds of R. iconiensis extracts were characterized and quantitated by LC–MS/MS. As a result, methanol extracts were not cytotoxic against A549, but were cytotoxic to the Colo 205, HepG2, MCF-7 and Beas-2b cell lines. Among the sub-extracts, dichloromethane, ethyl acetate and n-hexane sub-extracts of flowers and dichloromethane sub-extract of the stem were most cytotoxic against A549, HepG2, MCF-7 and Colo 205 cell lines, respectively. As sub-extracts were most effective against MCF-7 cancer cell line, it can be said that extracts might be effective in estrogen-sensitive cancer cells such as breast and cervix. The cytotoxic effects of sub-extracts can be explained by the variances of compounds and synergistic effects of different secondary metabolites.

癌症是一种导致身体器官或组织中细胞异常和不规则增殖的疾病。在土耳其植物区系中，有许多具有重要治疗意义的药用植物。Rhaponticoides iconiensis是土耳其特有的。在本研究中，采用MTT法评估了艾克森种的叶茎和花朵的甲醇提取物和提取物对Colo 205，A549，HepG2，MCF7和Beas-2b细胞系的细胞毒活性。LC-MS / MS鉴定和定量了R. iconiensis提取物的化合物。结果，甲醇提取物对A549没有细胞毒性，但对Colo 205，HepG2，MCF-7和Beas-2b细胞系具有细胞毒性。在子提取物中，二氯甲烷，乙酸乙酯和Ñ的花和茎的二氯甲烷子提取物己烷子萃取物最细胞毒性针对A549，HepG2细胞，MCF-7和Colo 205细胞系，分别。由于分提取物对MCF-7癌细胞最有效，因此可以说提取物可能对雌激素敏感性癌细胞（如乳腺癌和宫颈癌）有效。分提取物的细胞毒性作用可以通过化合物的差异和不同次级代谢产物的协同作用来解释。