N,N'-bis[(1-aryl-3-heteroaryl)propylidene]hydrazine dihydrochlorides, P1, P4 – P8, and R1 – R7, were assayed against human oral squamous cell carcinoma (HSC-2, HSC-3, HSC-4), human promyelocytic leukemia cell line (HL-60), and human normal oral cells (HGF, HPC, and HPLF) as non-tumor cells to evaluate their cytotoxic properties. Peplomycin was used as a reference compound. It was found that P- and R-series hydrazone compounds exhibited cytotoxicity in a range of 11 ± 0.68 – 300 ± 1.0 ± M. Compound P1 which is a non-substituted hydrazone containing piperidine ring and compound R2 which is a 4-methyl hydrazone derivative containing pyrrolidine ring showed the most potent cytotoxic activity. These hydrazone compounds may serve as promising candidates for further studies.

N，N- ' -双[（1-芳基-3-杂芳基）亚丙基]肼二盐酸盐，P1，P4 - P8，和R1 - R7，分别针对人口腔鳞状细胞癌测定（HSC-2，HSC-3，HSC -4），人类早幼粒细胞白血病细胞系（HL-60）和人类正常口腔细胞（HGF，HPC和HPLF）作为非肿瘤细胞来评估其细胞毒性。霉素用作为参考化合物。已发现P系列和R系列化合物在11±0.68 – 300±1.0±M的范围内表现出细胞毒性。化合物P1是含有哌啶环的非取代和化合物R2含有吡咯烷环的4-甲基衍生物具有最强的细胞毒活性。这些化合物可作为有希望的进一步研究的候选物。