Magnetic drug carriers are aimed at transporting the loaded drugs to the target site with the application of an external field. To realize this, a clever design of magnetic nanoparticles and their surface modification have to be achieved. Herein, we report the synthesis of ErFeO3 nanoparticles and their magnetic characteristics. In addition, we report a β-cyclodextrin-polyethylene glycol-folate conjugate and utilize it for coating the magnetic nanoparticles. The crystallinity and grain size of the nanoparticles are characterized using X-ray diffraction. The elemental composition of the nanoparticles and their orbital states are determined using XPS spectroscopy. The polymer-coated nanoparticles are soft ferromagnetic. The anticancer drug, camptothecin, is loaded on the polymer-coated nanoparticles with a loading percentage of about 88%. The efficacy of camptothecin gets enhanced when loaded on the magnetic nanocarrier and released in a sustained manner. Compared to the free form, the drug loaded on the nanocarrier shows an enhanced anticancer activity.

中文翻译：

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设计的聚（乙二醇）共轭-掺铒磁性纳米颗粒杂化载体：增强抗癌药物的活性

磁性载药器旨在通过施加外场将装载的药物运送到目标部位。为了实现这一点，必须实现磁性纳米粒子的巧妙设计及其表面改性。在此，我们报告了 ErFeO3 纳米粒子的合成及其磁特性。此外，我们报告了一种 β-环糊精-聚乙二醇-叶酸缀合物，并将其用于涂覆磁性纳米颗粒。使用 X 射线衍射表征纳米颗粒的结晶度和晶粒尺寸。纳米粒子的元素组成及其轨道状态使用 XPS 光谱确定。聚合物包覆的纳米粒子是软铁磁性的。抗癌药物喜树碱以约88%的负载百分比负载在聚合物包覆的纳米颗粒上。当加载在磁性纳米载体上并以持续方式释放时，喜树碱的功效得到增强。与游离形式相比，负载在纳米载体上的药物显示出增强的抗癌活性。