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Designed poly(ethylene glycol) conjugate-erbium-doped magnetic nanoparticle hybrid carrier: enhanced activity of anticancer drug

  • Materials for life sciences
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Abstract

Magnetic drug carriers are aimed at transporting the loaded drugs to the target site with the application of an external field. To realize this, a clever design of magnetic nanoparticles and their surface modification have to be achieved. Herein, we report the synthesis of ErFeO3 nanoparticles and their magnetic characteristics. In addition, we report a β-cyclodextrin-polyethylene glycol-folate conjugate and utilize it for coating the magnetic nanoparticles. The crystallinity and grain size of the nanoparticles are characterized using X-ray diffraction. The elemental composition of the nanoparticles and their orbital states are determined using XPS spectroscopy. The polymer-coated nanoparticles are soft ferromagnetic. The anticancer drug, camptothecin, is loaded on the polymer-coated nanoparticles with a loading percentage of about 88%. The efficacy of camptothecin gets enhanced when loaded on the magnetic nanocarrier and released in a sustained manner. Compared to the free form, the drug loaded on the nanocarrier shows an enhanced anticancer activity.

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Acknowledgement

The authors express gratitude to the Board of Research in Nuclear Sciences, Department of Atomic Energy, Government of India, for the project (No. 37(2)/14/17/2018-BRNS/37147).

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Authors and Affiliations

  1. Department of Chemistry and Department of Chemical Engineering, Hindustan Institute of Technology and Science, Chennai, Tamil Nadu, 603103, India

    Kiruthiga Kaliyamoorthi & Anitha Arivarasu

  2. Centre for Nanoscience and Genomics, Karunya Institute of Technology and Sciences, Coimbatore, Tamil Nadu, 641114, India

    Archana Sumohan Pillai, Aleyamma Alexander, Sivaraj Ramasamy & Israel V. M. V. Enoch

Authors
  1. Kiruthiga Kaliyamoorthi
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  2. Archana Sumohan Pillai
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  3. Aleyamma Alexander
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  6. Israel V. M. V. Enoch
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Correspondence to Israel V. M. V. Enoch.

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Kaliyamoorthi, K., Sumohan Pillai, A., Alexander, A. et al. Designed poly(ethylene glycol) conjugate-erbium-doped magnetic nanoparticle hybrid carrier: enhanced activity of anticancer drug. J Mater Sci 56, 3925–3934 (2021). https://doi.org/10.1007/s10853-020-05466-w

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