Delivering transgenes to human cells through transduction with viral vectors constitutes one of the most encouraging approaches in gene therapy. Lentivirus-derived vectors are among the most promising vectors for these approaches. When the genetic modification of the cell must be performed in vivo, efficient specific transduction of the cell targets of the therapy in the absence of off-targeting constitutes the Holy Grail of gene therapy. For viral therapy, this is largely determined by the characteristics of the surface proteins carried by the vector. In this regard, an important property of lentiviral vectors is the possibility of being pseudotyped by envelopes of other viruses, widening the panel of proteins with which they can be armed. Here, we discuss how this is achieved at the molecular level and what the properties and the potentialities of the different envelope proteins that can be used for pseudotyping these vectors are.

中文翻译：

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伪型慢病毒载体：当衣服感染病毒时

通过病毒载体的转导将转基因传递给人类细胞构成了基因治疗中最令人鼓舞的方法之一。慢病毒衍生的载体是用于这些方法的最有希望的载体。当必须在体内进行细胞的基因修饰时，在没有脱靶的情况下有效治疗细胞靶的特异性特异性转导构成基因治疗的圣杯。对于病毒疗法，这很大程度上取决于载体携带的表面蛋白的特性。在这方面，慢病毒载体的重要特性是可能被其他病毒的包膜假型化，从而拓宽了它们可用于武装的蛋白质范围。这里，