Self-reporting heavy atom-free photodynamic therapy agents,Organic & Biomolecular Chemistry

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Self-reporting heavy atom-free photodynamic therapy agents
Organic & Biomolecular Chemistry ( IF 2.9 ) Pub Date : 2020-11-06 , DOI: 10.1039/d0ob01944e
Gulsen Turkoglu ₁ , Gozde Kayadibi Koygun ₂ , Mediha Nur Zafer Yurt ₃ , Naime Demirok ₄ , Sundus Erbas-Cakmak ₁

Affiliation

Two novel, self-reporting distyryl BODIPY-based photodynamic therapy agents functionalized with singlet oxygen responsive imidazole and tertiary amine moieties are developed. Heavy atom-free photosensitizers are demonstrated to have efficient photodynamic action in MCF7 cells. The fluorescence intensity of the photosensitizers is shown to be reduced as a result of ¹O₂ generation without any significant change in photodynamic activity.

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