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Self-reporting heavy atom-free photodynamic therapy agents
Organic & Biomolecular Chemistry ( IF 2.9 ) Pub Date : 2020-11-06 , DOI: 10.1039/d0ob01944e
Gulsen Turkoglu 1 , Gozde Kayadibi Koygun 2 , Mediha Nur Zafer Yurt 3 , Naime Demirok 4 , Sundus Erbas-Cakmak 1
Affiliation  

Two novel, self-reporting distyryl BODIPY-based photodynamic therapy agents functionalized with singlet oxygen responsive imidazole and tertiary amine moieties are developed. Heavy atom-free photosensitizers are demonstrated to have efficient photodynamic action in MCF7 cells. The fluorescence intensity of the photosensitizers is shown to be reduced as a result of 1O2 generation without any significant change in photodynamic activity.

中文翻译:


自报告无重原子光动力治疗剂



开发了两种新型、自我报告的基于二苯乙烯基 BODIPY 的光动力治疗剂,其具有单线态氧响应性咪唑和叔胺部分。重无原子光敏剂被证明在 MCF7 细胞中具有有效的光动力作用。光敏剂的荧光强度由于1 O 2的生成而降低,而光动力活性没有任何显着变化。
更新日期:2020-11-13
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