Issue 46, 2020
From the journal:

Organic & Biomolecular Chemistry

Self-reporting heavy atom-free photodynamic therapy agents†

Gulsen Turkoglu,ab   Gozde Kayadibi Koygun, ORCID logo c   Mediha Nur Zafer Yurt,a   Naime Demirokd  and  Sundus Erbas-Cakmak ORCID logo *ab  

* Corresponding authors

a Research and Development Center for Diagnostic Kits (KIT-ARGEM) Konya Food and Agriculture University, Konya, Turkey

b Konya Food and Agriculture University, Department of Molecular Biology and Genetics, Konya, Turkey
E-mail: sundus.erbascakmak@gidatarim.edu.tr

c Selçuk University, Department of Nanotechnology and Advanced Materials, Konya, Turkey

d Üsküdar University, Department of Molecular Biology and Genetics, İstanbul, Turkey

Abstract

Two novel, self-reporting distyryl BODIPY-based photodynamic therapy agents functionalized with singlet oxygen responsive imidazole and tertiary amine moieties are developed. Heavy atom-free photosensitizers are demonstrated to have efficient photodynamic action in MCF7 cells. The fluorescence intensity of the photosensitizers is shown to be reduced as a result of 1O2 generation without any significant change in photodynamic activity.

Graphical abstract: Self-reporting heavy atom-free photodynamic therapy agents

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Article information

DOI
https://doi.org/10.1039/D0OB01944E
Article type
Communication
Submitted
22 Sep 2020
Accepted
06 Nov 2020
First published
06 Nov 2020

Org. Biomol. Chem., 2020,18, 9433-9437

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Self-reporting heavy atom-free photodynamic therapy agents

G. Turkoglu, G. Kayadibi Koygun, M. N. Z. Yurt, N. Demirok and S. Erbas-Cakmak, Org. Biomol. Chem., 2020, 18, 9433 DOI: 10.1039/D0OB01944E

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