In inflammatory rheumatic disorders, the immune system attacks and damages the connective tissues and invariably internal organs. During the past decade, remarkable advances having been made towards our understanding on the cellular and molecular mechanisms involved in rheumatic diseases. The discovery of IL-23/IL-17 axis and the delineation of its important role in the inflammation led to the introduction of many needed new therapeutic tools. We will present an overview of the rationale for targeting therapeutically the IL-23/IL-17 axis in rheumatic diseases and the clinical benefit which has been realized so far. Finally, we will discuss the complex interrelationship between IL-23 and IL-17 and the possible uncoupling in certain disease settings.

在炎性风湿性疾病中，免疫系统攻击并损害结缔组织和内脏器官。在过去的十年中，我们对风湿性疾病的细胞和分子机制的理解取得了显着进展。IL-23/IL-17 轴的发现及其在炎症中的重要作用的描述导致了许多需要的新治疗工具的引入。我们将概述在风湿性疾病中靶向治疗 IL-23/IL-17 轴的基本原理以及迄今为止已实现的临床益处。最后，我们将讨论 IL-23 和 IL-17 之间复杂的相互关系以及某些疾病环境中可能的解偶联。