Abstract

The lipid droplet (LD) is a highly dynamic organelle that maintains cellular lipid homeostasis in addition to storing energy sources. Current research suggests LDs are responsible for the transportation, storage and lipolysis-driven mobilization of lipids within cells. Here, we review the landscape of evidence for LD involvement in regulating lipid homeostasis. LD interactions with other organelles, particularly the endoplasmic reticulum, mitochondria, lysosomes (or vacuoles in yeast), and peroxisomes, highlight their importance for lipid transfer and metabolism.

中文翻译：

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跨真核生物的脂滴代谢：从酵母到人类的证据

摘要

脂质滴（LD）是一种高度动态的细胞器，除储存能量外还可以维持细胞脂质的稳态。当前的研究表明，LDs负责细胞内脂质的运输，存储和脂解驱动的动员。在这里，我们回顾了LD参与调节脂质稳态的证据。LD与其他细胞器的相互作用，特别是内质网，线粒体，溶酶体（或酵母中的液泡）和过氧化物酶体，突出了它们对于脂质转移和代谢的重要性。