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Lipid Droplet Metabolism Across Eukaryotes: Evidence from Yeast to Humans

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Abstract

The lipid droplet (LD) is a highly dynamic organelle that maintains cellular lipid homeostasis in addition to storing energy sources. Current research suggests LDs are responsible for the transportation, storage and lipolysis-driven mobilization of lipids within cells. Here, we review the landscape of evidence for LD involvement in regulating lipid homeostasis. LD interactions with other organelles, particularly the endoplasmic reticulum, mitochondria, lysosomes (or vacuoles in yeast), and peroxisomes, highlight their importance for lipid transfer and metabolism.

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This work was supported by the Natural Science Foundation of Guangdong Province, China (Grant Number 202015150224).

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  1. Department of Biochemistry and Molecular Biology, Guangdong Medical University, Dongguan, Guangdong, 523808, China

    Jie Huang, Xiaojia Chen, Feilong Zhang, Margarita Lin, Guorong Lin & Zhizhen Zhang

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Huang, J., Chen, X., Zhang, F. et al. Lipid Droplet Metabolism Across Eukaryotes: Evidence from Yeast to Humans. J Evol Biochem Phys 56, 396–405 (2020). https://doi.org/10.1134/S0022093020050026

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