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Association of HLA-DQ and IL13 gene variants with challenge-proven shrimp allergy in West Bengal, India
Immunogenetics ( IF 2.9 ) Pub Date : 2020-11-11 , DOI: 10.1007/s00251-020-01185-3
Arghya Laha , Amlan Ghosh , Saibal Moitra , Himani Biswas , Nimai Chandra Saha , Srijit Bhattacharya , Goutam Kumar Saha , Sanjoy Podder

Little is known about genetic factors and mechanisms underlying shrimp allergy. Genome-wide association studies identified HLA class-II and IL13 genes as highly plausible candidates for shrimp allergy. The present study was designed to investigate potential associations of HLA-DQ rs9275596, IL13 rs20541, and IL13 rs1800925 polymorphisms with challenge-proven shrimp allergy using the data from 532 people of West Bengal, India; selected on basis of positive skin prick test, elevated specific IgE and medical history. Risk genotypes, i.e., HLA-DQ rs9275596 CC, IL13 rs20541 AA, and IL13 rs1800925 TT, were found to be significantly associated with challenge positive shrimp allergy (P = 0.04, 0.01, and 0.03, respectively). Distribution of genotypes for HLA-DQ and IL13 polymorphisms in allergic and control subjects showed significant difference between younger (20–40 years) and older (> 40 years) age group (P = 0.006). Risk genotypes significantly associated with elevated shrimp-specific IgE. IL13 TA haplotype significantly associated with shrimp allergy and elevated specific IgE (P = 0.02). Synergistic effect of IL13 TA haplotype–HLA-DQ rs9275596 CC genotype interaction significantly elevated specific IgE (P = 0.03). The present study suggests that HLA-DQ and IL13 polymorphisms pose major risk for shrimp allergic patients in West Bengal, India and thus could be helpful for early target-specific therapeutic intervention in near future.



中文翻译:

HLA-DQ和IL13基因变异与印度西孟加拉邦经挑战验证的虾过敏相关

对虾过敏的遗传因素和机制知之甚少。全基因组关联研究确定HLA II类和IL13基因为虾过敏的高度可信候选者。本研究旨在使用来自印度西孟加拉邦的532人的数据,调查HLA-DQ rs9275596,IL13 rs20541和IL13 rs1800925多态性与挑战验证的虾过敏的潜在关联。根据阳性皮肤点刺试验,升高的特异性IgE和病史进行选择。发现危险基因型,即HLA-DQ rs9275596 CC,IL13 rs20541 AA和IL13 rs1800925 TT与挑战阳性虾过敏显着相关(P 分别为0.04、0.01和0.03)。HLA-DQ和IL13多态性的基因型分布在变态反应和对照受试者中显示,年龄较小的年龄段(20-40岁)和年龄较大的年龄段(> 40岁)之间存在显着差异(P  = 0.006)。风险基因型与虾特异性IgE升高显着相关。IL13 TA单倍型与虾过敏和特异性IgE升高显着相关(P  = 0.02)。IL13 TA单倍型-HLA-DQ rs9275596 CC基因型相互作用的协同效应显着提高了特异性IgE(P  = 0.03)。本研究表明,HLA-DQ和IL13多态性对印度西孟加拉邦的虾过敏患者构成主要风险,因此可能在不久的将来对早期针对靶标的治疗干预有所帮助。

更新日期:2020-11-12
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