Little is known about genetic factors and mechanisms underlying shrimp allergy. Genome-wide association studies identified HLA class-II and IL13 genes as highly plausible candidates for shrimp allergy. The present study was designed to investigate potential associations of HLA-DQ rs9275596, IL13 rs20541, and IL13 rs1800925 polymorphisms with challenge-proven shrimp allergy using the data from 532 people of West Bengal, India; selected on basis of positive skin prick test, elevated specific IgE and medical history. Risk genotypes, i.e., HLA-DQ rs9275596 CC, IL13 rs20541 AA, and IL13 rs1800925 TT, were found to be significantly associated with challenge positive shrimp allergy (P = 0.04, 0.01, and 0.03, respectively). Distribution of genotypes for HLA-DQ and IL13 polymorphisms in allergic and control subjects showed significant difference between younger (20–40 years) and older (> 40 years) age group (P = 0.006). Risk genotypes significantly associated with elevated shrimp-specific IgE. IL13 TA haplotype significantly associated with shrimp allergy and elevated specific IgE (P = 0.02). Synergistic effect of IL13 TA haplotype–HLA-DQ rs9275596 CC genotype interaction significantly elevated specific IgE (P = 0.03). The present study suggests that HLA-DQ and IL13 polymorphisms pose major risk for shrimp allergic patients in West Bengal, India and thus could be helpful for early target-specific therapeutic intervention in near future.

对虾过敏的遗传因素和机制知之甚少。全基因组关联研究确定HLA II类和IL13基因为虾过敏的高度可信候选者。本研究旨在使用来自印度西孟加拉邦的532人的数据，调查HLA-DQ rs9275596，IL13 rs20541和IL13 rs1800925多态性与挑战验证的虾过敏的潜在关联。根据阳性皮肤点刺试验，升高的特异性IgE和病史进行选择。发现危险基因型，即HLA-DQ rs9275596 CC，IL13 rs20541 AA和IL13 rs1800925 TT与挑战阳性虾过敏显着相关（P 分别为0.04、0.01和0.03）。HLA-DQ和IL13多态性的基因型分布在变态反应和对照受试者中显示，年龄较小的年龄段（20-40岁）和年龄较大的年龄段（> 40岁）之间存在显着差异（P  = 0.006）。风险基因型与虾特异性IgE升高显着相关。IL13 TA单倍型与虾过敏和特异性IgE升高显着相关（P  = 0.02）。IL13 TA单倍型-HLA-DQ rs9275596 CC基因型相互作用的协同效应显着提高了特异性IgE（P  = 0.03）。本研究表明，HLA-DQ和IL13多态性对印度西孟加拉邦的虾过敏患者构成主要风险，因此可能在不久的将来对早期针对靶标的治疗干预有所帮助。