Background

Toxoplasma gondii is the global protozoa that could cause contamination in warm-blooded animals and is considered among the opportunistic pathogens in immunocompromised patients. Among the people at risk, toxoplasmosis infection can lead to the incidence of severe clinical manifestations, encephalitis, chorioretinitis, and even death.

Purpose

The present research is focused on the new research for the treatment of toxoplasmosis parasitic disease using medicinal herbs.

Methods

The search was performed in five English databases, including Scopus, PubMed, Web of Science, EMBASE, and Google Scholar up from 2010 to December 2019. Studies in any language were entered in the searching step if they had an English abstract. The words and terms were used as a syntax with specific tags of each database.

Results

Out of 1832 studies, 36 were eligible to be reviewed. The findings showed that 17 studies (47%) were performed in vitro, 14 studies (39%) in vivo, and 5 studies (14%) both in vivo and in vitro.

Conclusion

The studies showed that the plant extracts can be a good alternative in reducing the toxoplasmosis effects in the host and the herbal extracts can be used to produce natural product-based drugs affecting toxoplasmosis with fewer side-effects than synthetic drugs.

中文翻译：

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药用植物在治疗弓形虫感染中的实验作用：系统评价

背景

弓形虫是一种全球性原生动物，可导致温血动物污染，被认为是免疫功能低下患者的机会性病原体之一。在高危人群中，弓形虫感染可导致严重的临床表现、脑炎、脉络膜视网膜炎，甚至死亡。

目的

目前的研究重点是利用草药治疗弓形体寄生虫病的新研究。

方法

从 2010 年到 2019 年 12 月，在 Scopus、PubMed、Web of Science、EMBASE 和 Google Scholar 等五个英文数据库中进行了搜索。如果有英文摘要，则在搜索步骤中输入任何语言的研究。单词和术语被用作带有每个数据库特定标签的语法。

结果

在 1832 项研究中，36 项符合审查条件。结果表明，17项研究（47%）在体外进行，14项研究（39%）在体内进行，5项研究（14%）在体内和体外进行。

结论

研究表明，植物提取物是减少宿主弓形虫病影响的良好替代品，草药提取物可用于生产影响弓形虫病的天然药物，其副作用比合成药物少。