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The Experimental Role of Medicinal Plants in Treatment of Toxoplasma gondii Infection: A Systematic Review

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Abstract

Background

Toxoplasma gondii is the global protozoa that could cause contamination in warm-blooded animals and is considered among the opportunistic pathogens in immunocompromised patients. Among the people at risk, toxoplasmosis infection can lead to the incidence of severe clinical manifestations, encephalitis, chorioretinitis, and even death.

Purpose

The present research is focused on the new research for the treatment of toxoplasmosis parasitic disease using medicinal herbs.

Methods

The search was performed in five English databases, including Scopus, PubMed, Web of Science, EMBASE, and Google Scholar up from 2010 to December 2019. Studies in any language were entered in the searching step if they had an English abstract. The words and terms were used as a syntax with specific tags of each database.

Results

Out of 1832 studies, 36 were eligible to be reviewed. The findings showed that 17 studies (47%) were performed in vitro, 14 studies (39%) in vivo, and 5 studies (14%) both in vivo and in vitro.

Conclusion

The studies showed that the plant extracts can be a good alternative in reducing the toxoplasmosis effects in the host and the herbal extracts can be used to produce natural product-based drugs affecting toxoplasmosis with fewer side-effects than synthetic drugs.

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Authors and Affiliations

  1. Razi Herbal Medicines Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran

    Kourosh Cheraghipour, Leila Masoori, Behrooz Ezzatpour, Ali Sheikhian, Vahid Malekara & Hossein Mahmoudvand

  2. Department of Parasitology and Mycology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran

    Mona Roozbehani

  3. Student Research Committee, Lorestan University of Medical Sciences, Khorramabad, Iran

    Massumeh Niazi

  4. Department of Laboratory Sciences, School of Medical Sciences, Sirjan Faculty of Medical Sciences, Kerman, Iran

    Omid Mardanshah

  5. Lorestan University of Medical Sciences, Khorramabad, Iran

    Kobra Moradpour

Authors
  1. Kourosh Cheraghipour
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  2. Leila Masoori
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  3. Behrooz Ezzatpour
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  5. Ali Sheikhian
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  7. Massumeh Niazi
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  9. Kobra Moradpour
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  10. Hossein Mahmoudvand
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Corresponding author

Correspondence to Hossein Mahmoudvand.

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Cheraghipour, K., Masoori, L., Ezzatpour, B. et al. The Experimental Role of Medicinal Plants in Treatment of Toxoplasma gondii Infection: A Systematic Review. Acta Parasit. 66, 303–328 (2021). https://doi.org/10.1007/s11686-020-00300-4

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  • DOI: https://doi.org/10.1007/s11686-020-00300-4

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