Purpose/objective

The aim of this study was to quantify circulating fibroblast growth factor 21 (FGF-21) changes during and immediately after acute exercise and, based on body weight, to identify the subgroups exhibiting the largest response.

Methods

The PubMed, Web of Science, and Cochrane Library electronic databases were searched up to December 2019 for studies published in English peer-reviewed journals. Studies that evaluated the effects of acute exercise on FGF-21 concentrations immediately after and 1 and 3 h post-exercise in adults were included. Random effects models were used for analyses, with data reported as standardized mean difference (SMD) and 95% confidence interval, and the risk of heterogeneity was evaluated. Subgroup analysis of subjects with normal weight and obesity/overweight was performed.

Results

A total of seven studies involving 125 participants (age 35.95 (21–64) years and BMI 25.89 (21.30–35.46) kg/m²) were included. Overall, acute exercise increased FGF-21 (d = 0.18; 95% CI 0.01 to 0.35, p = 0.02) and this remained for 1 h post-exercise FGF-21 (d = 0.59; 95% CI 0.33 to 0.86, p = 0.001). Three hours after exercise, FGF-21 was restored to near baseline values (d = − 0.05; 95% CI − 0.34 to 0.22, p = 0.68). Acute exercise raised FGF-21 concentrations in normal weight participants (d = 0.57, p = 0.001) and tended to increase in overweight and obese participants (d = 0.79, p = 0.05) 1 h post-exercise.

Conclusion

Acute exercise increases circulating FGF-21, irrespective of body weight.

中文翻译：

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急性运动对成人运动后即刻和运动后早期 FGF-21 浓度的影响：系统评价和荟萃分析

目的/目标

本研究的目的是量化急性运动期间和之后立即循环的成纤维细胞生长因子 21 (FGF-21) 变化，并根据体重确定表现出最大反应的亚组。

方法

在 PubMed、Web of Science 和 Cochrane 图书馆电子数据库中搜索了截至 2019 年 12 月在英语同行评审期刊上发表的研究。包括评估急性运动对成人运动后立即和运动后 1 小时和 3 小时 FGF-21 浓度影响的研究。使用随机效应模型进行分析，数据报告为标准化平均差（SMD）和 95% 置信区间，并评估异质性风险。对体重正常和肥胖/超重的受试者进行亚组分析。

结果

共纳入 7 项研究，涉及 125 名参与者（年龄 35.95 (21–64) 岁，BMI 25.89 (21.30–35.46) kg/m ²）。总体而言，急性运动增加 FGF-21（d = 0.18；95% CI 0.01 至 0.35，p = 0.02），并且在运动后 FGF-21 保持 1 小时（d = 0.59；95% CI 0.33 至 0.86，p = 0.001）。运动后三小时，FGF-21 恢复到接近基线值（d = - 0.05；95% CI - 0.34 至 0.22，p = 0.68）。急性运动会提高正常体重参与者的 FGF-21 浓度 ( d = 0.57, p = 0.001)，并且在超重和肥胖参与者中趋于增加 ( d = 0.79,p = 0.05) 运动后 1 小时。

结论

无论体重如何，急性运动都会增加循环 FGF-21。