The effect of 2-ethyl-3-hydroxy-6-methylpyridine nitroxy succinate (1) on heart, brain, and liver tissues of experimental animals (C57/b1 mice) was studied by EPR. It was shown that compound 1, like nicorandil, increases the nitric oxide production in cells and, like mexidol, protects iron-sulfur clusters of the mitochondrial respiratory chain in heart, brain, and liver tissues of animals against oxidative damage. Experimental evidence was obtained that under oxidative conditions, mitochondrial iron-sulfur clusters are maintained in the reduced functional state due to the presence of succinate (as nitroxy succinic acid), as a metabolite of the tricarboxylic acid cycle, in compound 1.

中文翻译：

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2-乙基-3-羟基-6-甲基吡啶硝基琥珀酸酯作为多功能杂化结构

通过 EPR 研究了 2-乙基-3-羟基-6-甲基吡啶硝基琥珀酸酯 (1) 对实验动物（C57/b1 小鼠）的心脏、大脑和肝脏组织的影响。结果表明，化合物 1 与尼可地尔一样，可增加细胞中一氧化氮的产生，并且与美西多一样，可保护动物心脏、大脑和肝脏组织中线粒体呼吸链的铁硫簇免受氧化损伤。获得的实验证据表明，在氧化条件下，由于化合物 1 中存在琥珀酸盐（如硝基琥珀酸）作为三羧酸循环的代谢物，线粒体铁硫簇保持在还原的功能状态。