Abstract
The effect of 2-ethyl-3-hydroxy-6-methylpyridine nitroxy succinate (1) on heart, brain, and liver tissues of experimental animals (C57/b1 mice) was studied by EPR. It was shown that compound 1, like nicorandil, increases the nitric oxide production in cells and, like mexidol, protects iron-sulfur clusters of the mitochondrial respiratory chain in heart, brain, and liver tissues of animals against oxidative damage. Experimental evidence was obtained that under oxidative conditions, mitochondrial iron-sulfur clusters are maintained in the reduced functional state due to the presence of succinate (as nitroxy succinic acid), as a metabolite of the tricarboxylic acid cycle, in compound 1.
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The study was performed within the framework of the state assignment (theme AAAA-A19-119071890015-6).
Russian Chemical Bulletin, International Edition, Vol. 69, No. 10, pp. 1999–2003, October, 2020
Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 10, pp. 1999–2003, October, 2020.
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Bogatyrenko, T.N., Kuropteva, Z.V., Baider, L.M. et al. 2-Ethyl-3-hydroxy-6-methylpyridine nitroxy succinate as a multifunctional hybrid structure. Russ Chem Bull 69, 1999–2003 (2020). https://doi.org/10.1007/s11172-020-2991-4
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DOI: https://doi.org/10.1007/s11172-020-2991-4