PI3K–Akt signalling downstream of cell-surface receptor activation has long been thought to occur at the plasma membrane. However, surprising evidence now reveals activation of PI3Kα-mediated PI(3,4,5)P3 synthesis on endosomal membranes that is dependent upon the interaction of PI3Kα with the microtubule-associated protein MAP4.

中文翻译：

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内体 PI3K 激活的 MAP

长期以来，人们一直认为细胞表面受体激活下游的 PI3K-Akt 信号发生在质膜上。然而，令人惊讶的证据现在揭示了内体膜上 PI3Kα 介导的 PI(3,4,5)P3 合成的激活，这取决于 PI3Kα 与微管相关蛋白 MAP4 的相互作用。