PI3K–Akt signalling downstream of cell-surface receptor activation has long been thought to occur at the plasma membrane. However, surprising evidence now reveals activation of PI3Kα-mediated PI(3,4,5)P3 synthesis on endosomal membranes that is dependent upon the interaction of PI3Kα with the microtubule-associated protein MAP4.
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References
Thorpe, L. M., Yuzugullu, H. & Zhao, J. J. Nat. Rev. Cancer 15, 7–24 (2015).
Liu, S. L. et al. Mol. Cell 71, 1092–1104.e5 (2018).
Thapa, N. et al. Nat. Cell Biol. https://doi.org/10.1038/s41556-020-00596-4 (2020).
Bilanges, B., Posor, Y. & Vanhaesebroeck, B. Nat. Rev. Mol. Cell Biol. 20, 515–534 (2019).
Ebner, M., Lučić, I., Leonard, T. A. & Yudushkin, I. Mol. Cell 65, 416–431.e6 (2017).
Kapeller, R., Chakrabarti, R., Cantley, L., Fay, F. & Corvera, S. Mol. Cell. Biol. 13, 6052–6063 (1993).
Sato, M., Ueda, Y., Takagi, T. & Umezawa, Y. Nat. Cell Biol. 5, 1016–1022 (2003).
Ramos, A. R., Ghosh, S. & Erneux, C. J. Lipid Res. 60, 276–286 (2019).
Balla, A., Tuymetova, G., Barshishat, M., Geiszt, M. & Balla, T. J. Biol. Chem. 277, 20041–20050 (2002).
Schill, N. J. & Anderson, R. A. Biochem. J. 422, 473–482 (2009).
Choi, S. et al. Nat. Cell Biol. 18, 1324–1335 (2016).
Smith, J. M., Hedman, A. C. & Sacks, D. B. Trends Cell Biol. 25, 171–184 (2015).
Zewe, J. P. et al. J. Cell Biol. https://doi.org/10.1083/jcb.201906127 (2020).
Pemberton, J. G. et al. J. Cell Biol. https://doi.org/10.1083/jcb.201906130 (2020).
Kim, Y. J., Guzman-Hernandez, M. L., Wisniewski, E. & Balla, T. Dev. Cell 33, 549–561 (2015).
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Batrouni, A.G., Baskin, J.M. A MAP for PI3K activation on endosomes. Nat Cell Biol 22, 1292–1294 (2020). https://doi.org/10.1038/s41556-020-00597-3
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DOI: https://doi.org/10.1038/s41556-020-00597-3
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