Objectives

This study aimed to analyze the effect of whole-body vibration (WBV) on metabolic parameters using the monosodium l-glutamate (MSG) model of obesity.

Method

MSG-obese rats that were exposed to WBV on a vibrating platform with 60 Hz frequency, 2 mm amplitude, three times/week, 10 min/day, during eight weeks (from postnatal day (PN) 80 to PN136). Blood glucose, creatine kinases (CK and CK-MB) and lipid profile through plasma and liver levels of lipids and lipoproteins were evaluated. Morphology and oxidative stress of adipose and hepatic tissues were further evaluated.

Results

When performing a WBV exercise, animals showed contrasting metabolic responses. Vibration Control group (CTL-WBV) presented a reduction in CK and liver triacylglycerol, an increase in glucose, lactate, total cholesterol, liver cholesterol, and LDL while MSG Vibration group (MSG-WBV) showed an increase in total triacylglycerol, VLDL, lactate, CK, liver cholesterol, additional liver lipid peroxidation and LDL, total cholesterol and CKMB reduction.

Conclusion

Even although the MSG is a model of impacting injury, the metabolic demand of WBV exercise was able to induce mobilization of substrates, highlighting the lipid mobilization in obese animals, it should be used as a metabolic rehabilitation tool in patients with metabolic diseases, such as obesity and diabetes.

中文翻译：

---

全身振动促进下丘脑肥胖大鼠的脂质动员

 目标

本研究旨在利用L-谷氨酸单钠 (MSG) 肥胖模型分析全身振动 (WBV) 对代谢参数的影响。

 方法

MSG 肥胖大鼠在八周内（从出生后 (PN) 80 到 PN136）在频率为 60 Hz、振幅为 2 mm 的振动平台上暴露于 WBV，每周 3 次，每天 10 分钟。通过血浆和肝脏脂质和脂蛋白水平评估血糖、肌酸激酶（CK 和 CK-MB）和血脂谱。进一步评估脂肪和肝组织的形态和氧化应激。

 结果

当进行 WBV 运动时，动物表现出截然不同的代谢反应。振动对照组 (CTL-WBV) 的 CK 和肝三酰甘油减少，葡萄糖、乳酸、总胆固醇、肝胆固醇和 LDL 增加，而 MSG 振动组 (MSG-WBV) 则显示总三酰甘油、VLDL、乳酸、CK、肝脏胆固醇、额外肝脏脂质过氧化和低密度脂蛋白、总胆固醇和 CK 减少MB。

 结论

尽管MSG是影响损伤的模型，但WBV运动的代谢需求能够诱导底物动员，突出了肥胖动物中的脂质动员，它应该用作代谢性疾病患者的代谢康复工具，例如肥胖和糖尿病。