A new sesquiterpenoid derivative, 13-hydroxy-1-oxocurzerenone (1), has been isolated from the rhizomes of Curcuma zedoaria, together with seven known compounds, 1-oxocurzerenone (2), curcolone (3), curcumenone (4), procurcumenol (5), curcumenol (6), zerumin A (7), and labda-8(17), 12-diene-15,16-dial (8). The structure of the new compound 1 was determined through spectroscopic and MS analyses. Among the isolates, 13-hydroxy-1-oxocurzerenone (1), procurcumenol (5), and zerumin A (7) exhibited cytotoxicities, with IC50 values of 3.48, 12.36, and 14.08 μM, respectively, against the DLD-1 cell line. Curcumenone (4) and curcumenol (6) showed cytotoxic effects, with IC50 values of 8.97 and 10.26 μM, respectively, against the MCF-7 cell line. In addition, 13-hydroxy-1-oxocurzerenone (1), 1-oxocurzerenone (2), zerumin A (7), and labda-8(17),12-diene-15,16-dial (8) showed potent inhibition, with IC50 values of 4.63, 6.48, 16.57, and 18.45 μM, respectively, against LPS-induced NO generation.

中文翻译：

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一种新的倍半萜类和莪术生物活性成分

从莪术的根茎中分离出一种新的倍半萜类衍生物 13-hydroxy-1-oxocurzerenone (1)，以及七种已知化合物，1-oxocurzerenone (2)、curcolone (3)、curcumenone (4)、procurcumenol (5)、姜黄素 (6)、Zerumin A (7) 和 labda-8(17)、12-diene-15,16-dial (8)。新化合物 1 的结构是通过光谱和 MS 分析确定的。在分离株中，13-羟基-1-氧代姜黄酮 (1)、原姜黄烯醇 (5) 和泽鲁明 A (7) 表现出细胞毒性，对 DLD-1 细胞系的 IC50 值分别为 3.48、12.36 和 14.08 μM . Curcumenone (4) 和 curcumenol (6) 显示出细胞毒性作用，对 MCF-7 细胞系的 IC50 值分别为 8.97 和 10.26 μM。此外，13-羟基-1-oxocurzerenone (1), 1-oxocurzerenone (2), zerumin A (7), and labda-8(17),12-diene-15,