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A New Sesquiterpenoid and Bioactive Constituents of Curcuma zedoaria

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A new sesquiterpenoid derivative, 13-hydroxy-1-oxocurzerenone (1), has been isolated from the rhizomes of Curcuma zedoaria, together with seven known compounds, 1-oxocurzerenone (2), curcolone (3), curcumenone (4), procurcumenol (5), curcumenol (6), zerumin A (7), and labda-8(17), 12-diene-15,16-dial (8). The structure of the new compound 1 was determined through spectroscopic and MS analyses. Among the isolates, 13-hydroxy-1-oxocurzerenone (1), procurcumenol (5), and zerumin A (7) exhibited cytotoxicities, with IC50 values of 3.48, 12.36, and 14.08 μM, respectively, against the DLD-1 cell line. Curcumenone (4) and curcumenol (6) showed cytotoxic effects, with IC50 values of 8.97 and 10.26 μM, respectively, against the MCF-7 cell line. In addition, 13-hydroxy-1-oxocurzerenone (1), 1-oxocurzerenone (2), zerumin A (7), and labda-8(17),12-diene-15,16-dial (8) showed potent inhibition, with IC50 values of 4.63, 6.48, 16.57, and 18.45 μM, respectively, against LPS-induced NO generation.

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Acknowledgment

This research was supported by a grant from Ministry of Science and Technology, Taiwan (MOST 106-2320-B-010-033-MY3), awarded to Prof. J.-J. Chen. This work was also supported by grants from Pingtung Christian Hospital (PS 109030 and PS 108030), Yuan′s General Hospital (YGH 20-006 and YGH 19-027), and Tajen University (109004). Jen-Wen Hsiao and Chien-Liang Lin have contributed equally to this manuscript.

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Authors and Affiliations

  1. Department of Pharmacy, Pingtung Christian Hospital, 900, Pingtung, Taiwan

    Jen-Wen Hsiao

  2. Department of Pharmacy, Tajen University, 907, Pingtung, Taiwan

    Li-Chai Chen

  3. Department of Pharmacy, FooYin University Hospital, 928, Pingtung, Taiwan

    Chien-Liang Lin

  4. Institute of Microbiology and Immunology, National Defense Medical Center, 114, Taipei, Taiwan

    Tsung-Hsien Chang

  5. Department of Biological Sciences, National Sun Yat-Sen University, 804, Kaohsiung, Taiwan

    Chun-Lin Chen

  6. National Museum of Marine Biology and Aquarium, 944, Pingtung, Taiwan

    Ping-Jyun Sung

  7. Bioresource Collection and Research Center (BCRC), Food Industry Research and Development Institute (FIRDI), 300, Hsinchu, Taiwan

    Ming-Jen Cheng

  8. Department of Pharmacy, Yuan’s General Hospital, 802, Kaohsiung, Taiwan

    Ching-Ju Hung

  9. Faculty of Pharmacy, School of Pharmaceutical Sciences, National Yang-Ming University, 112, Taipei, Taiwan

    Jih-Jung Chen

  10. Department of Medical Research, China Medical University Hospital, 404, Taichung, Taiwan

    Jih-Jung Chen

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  1. Jen-Wen Hsiao
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  2. Li-Chai Chen
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  3. Chien-Liang Lin
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  4. Tsung-Hsien Chang
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  5. Chun-Lin Chen
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  6. Ping-Jyun Sung
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  7. Ming-Jen Cheng
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  8. Ching-Ju Hung
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  9. Jih-Jung Chen
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Corresponding author

Correspondence to Jih-Jung Chen.

Additional information

Published in Khimiya Prirodnykh Soedinenii, No. 6, November–December, 2020, pp. 923–926.

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Hsiao, JW., Chen, LC., Lin, CL. et al. A New Sesquiterpenoid and Bioactive Constituents of Curcuma zedoaria. Chem Nat Compd 56, 1076–1080 (2020). https://doi.org/10.1007/s10600-020-03230-9

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  • DOI: https://doi.org/10.1007/s10600-020-03230-9

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