In the present work, amine-functionalized nanodiamonds (NDs) have been encapsulated in liposomes and studied in order to observe the modification of their photoluminescence properties. NDs were functionalized with aromatic amines such as 1-aminopyrene and 2-aminofluorene, and the aliphatic amine 1-octadecylamine. Morphology, structural and optical properties of NDs and amine-modified NDs were analyzed by transmission electron microscopy, atomic force microscopy, scanning electron microscopy, and photoluminescence. The amine-functionalized NDs were successfully encapsulated in lecithin liposomes prepared by the green and conventional methods. The obtained results show significant changes in photoluminescent properties of functionalized NDs, and were more potentialized after liposome encapsulation. Our findings could be applied in the development of new kinds of water-dispersible fluorescent hybrids, liposome-NDs, with the capability of drug encapsulation for use in diagnostics and therapy (theragnostic liposomes). All-optical sensors with possibilities for tailoring their response for other biomedical applications can be also contemplated.

在目前的工作中，胺官能化的纳米金刚石（NDs）已被封装在脂质体中并进行了研究，以观察其光致发光性能的变化。ND用芳族胺（例如1-氨基py和2-氨基芴）和脂肪族胺1-十八烷基胺官能化。通过透射电子显微镜，原子力显微镜，扫描电子显微镜和光致发光分析了ND和胺改性的ND的形态，结构和光学性质。将胺官能化的NDs成功地封装在通过绿色和常规方法制备的卵磷脂脂质体中。获得的结果表明功能化的NDs的光致发光特性发生了显着变化，并且在脂质体包封后更有潜力。我们的发现可用于开发新型水分散型荧光杂交体脂质体-ND，具有药物包封能力，可用于诊断和治疗（鼻窦炎脂质体）。也可以考虑具有针对其他生物医学应用调整其响应的可能性的全光学传感器。